{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:53:35Z","timestamp":1767084815550},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To analyze the variations between maternal complications and perinatal outcome among women with complete hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome, partial HELLP syndrome, and women with severe pre\u2010eclampsia and normal laboratory tests. We also examine the effect of corticosteroid therapy for treatment of HELLP.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this retrospective study, six patients with complete HELLP syndrome and 46 with partial HELLP syndrome, were compared and contrasted with 212 patients with severe pre\u2010eclampsia but without HELLP syndrome.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In Protocol 1, multiple organ dysfunction syndrome (MODS) was the strongest morbidity factor associated with patients among complete HELLP, partial HELLP, and severe pre\u2010eclampsia. After post\u2010hoc analysis, disseminated intravascular coagulation (DIC) was the significant outcome variable between complete and partial HELLP. In Protocol 2, after adjustment, we found that MODS (adjusted OR, 15.2, 95% CI, 6.18\u201335.53; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001); Apgar score less than 5 at 1\u2003minute (adjusted OR, 2.17, 95% CI, 0.94\u20135.01; <jats:italic>P<\/jats:italic>\u2003=\u20030.069) and DIC (adjusted OR, 9.51, 95% CI, 1.68\u201353.7, <jats:italic>P<\/jats:italic>\u2003=\u20030.011) remained significantly associated with HELLP syndrome. There was a favorable outcome found in the complete HELLP group. Neither the dexamethasone group nor the aggressive therapy group could benefit from the treatment protocol.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The different categories of HELLP syndrome, the protocol 1 and protocol 2 have been noted as differential effects on pregnancy outcome. MODS and DIC would be two significant outcome variables and corticosteroid therapy may not benefit HELLP patients.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2006.00468.x","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T11:10:17Z","timestamp":1163502617000},"page":"550-558","source":"Crossref","is-referenced-by-count":16,"title":["Comparisons of maternal and perinatal outcomes in Taiwanese women with complete and partial HELLP syndrome and women with severe pre\u2010eclampsia without HELLP"],"prefix":"10.1111","volume":"32","author":[{"given":"Ching\u2010Ming","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuenn\u2010Dyh","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Jen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u2010Shine","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195401212500301"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.12968\/hosp.1999.60.4.1089"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.033"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90266-8"},{"key":"e_1_2_5_6_2","first-page":"751","article-title":"Pre\u2010eclampsia associated with the syndrome of hemolysis, elevated liver enzymes and low platelets in severe pre\u2010eclampsia\u2010eclampsia","volume":"62","author":"McKenna J","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90043-I"},{"key":"e_1_2_5_8_2","first-page":"25","article-title":"Maternal mortality in a maternal\u2010fetal medicine intensive care unit","volume":"35","author":"Kirshon B","year":"1990","journal-title":"J Reprod Med"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199011000-00001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70178-X"},{"key":"e_1_2_5_11_2","first-page":"1689","article-title":"Report on high blood pressure in pregnancy","volume":"163","author":"National High Blood Pressure Education Working Group.","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000126245.35811.2a"},{"key":"e_1_2_5_13_2","first-page":"1606","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Munford RS","year":"2005"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082648"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00475-7"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)00281-2"},{"key":"e_1_2_5_17_2","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2001"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91429-Z"},{"key":"e_1_2_5_19_2","first-page":"141","volume-title":"Hypertension in Pregnancy","author":"Martin JN","year":"2003"},{"key":"e_1_2_5_20_2","first-page":"319","article-title":"Pregnancy Outcome in 303 Cases with Severe Pre\u2010eclampsia","volume":"64","author":"Sibai BM","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260525"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106179"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199909000-00009"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(02)42241-3"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2002.076"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70343-1"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200206000-00004"},{"key":"e_1_2_5_28_2","first-page":"987","volume-title":"William Obstetrics","author":"Cunningham FG","year":"2005"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.037"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2006.00468.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2006.00468.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T19:40:21Z","timestamp":1697398821000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2006.00468.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,14]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1447-0756.2006.00468.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2006.00468.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,14]]}}}