{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:16:49Z","timestamp":1783070209862,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To compare the efficacy of a single dose of 100\u2003\u00b5g intramuscular carbetocin to a single dose of intramuscular syntometrine (0.5\u2003mg ergometrine and 5IU oxytocin), in preventing post\u2010partum hemorrhage (PPH) in high risk patients following vaginal delivery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A prospective, randomized controlled study was conducted in a tertiary hospital where 120 pregnant women with risk factors for PPH who delivered vaginally were randomized into two groups: the study group where 100\u2003\u00b5g intramuscular carbetocin was administered and the control group, who received intramuscular syntometrine. Outcome measures compared included changes in vital signs, amount of intrapartum blood loss, uterine fundal position, addition of another oxytocic agent, side\u2010effects of the drugs, amount of lochia and hemoglobin drop after 24 hours post\u2010partum. Incidence of PPH or other adverse events were also compared.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were no significant differences in terms of requirement for additional oxytocic agents, time interval to well contracted uterus, blood transfusion requirements, adverse effects or complications. There was a significantly lower mean estimated blood loss in the carbetocin group compared to the syntometrine group (244\u2003\u00b1\u2003114\u2003mL vs 343\u2003\u00b1\u2003143\u2003mL, 95% CI 52\u2013146\u2003mL). There was also a significantly reduced drop in hemoglobin in the carbetocin group compared to the syntometrine group (0.3\u2003\u00b1\u20030.2\u2003g\/dL vs 0.4\u2003\u00b1\u20030.2\u2003g\/dL, 95% CI 0.1\u20130.2\u2003g\/dL).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Intramuscular carbetocin may be more effective than intramuscular syntometrine in reducing post\u2010partum blood loss and the drop in hemoglobin level.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2008.00829.x","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T03:04:33Z","timestamp":1221620673000},"page":"48-54","source":"Crossref","is-referenced-by-count":30,"title":["Carbetocin versus syntometrine in prevention of post\u2010partum hemorrhage following vaginal delivery"],"prefix":"10.1111","volume":"35","author":[{"given":"Kampan","family":"Nirmala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani Amelia","family":"Zainuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Azurah Abdul","family":"Ghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Zulkifli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Abdul","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Maternal Mortality:Global Factbook","author":"Abou ZC","year":"1991"},{"key":"e_1_2_5_3_2","volume-title":"Why Mothers Die. 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