{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:48:05Z","timestamp":1777618085192,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:00:00Z","timestamp":1309910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To identify the prenatal events associated with adverse outcome in babies born at less than 32\u2003weeks' gestation, including antenatal magnesium sulfate treatment.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A case\u2013control study was performed to examine the effect of long\u2010term tocolysis with MgSO<jats:sub>4<\/jats:sub>. Long\u2010term neonatal and infantile adverse outcomes were defined as one of the following: intraventricular hemorrhage, periventricular leukomalacia, cerebral palsy and infantile death.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Data were analyzed for 425 cases (236 who received magnesium sulfate and 189 control cases who did not). Perinatal deaths included 13 cases that had received magnesium (5.5%) and 17 control cases (9.0%). Long\u2010term neonatal and infantile adverse outcomes were noted in 80 cases. The factor associated with an increased risk of combined adverse outcome after adjustment for confounding effects was the administration of corticosteroids (adjusted odds ratio [OR] 0.47, 95% confidence interval [CI] 0.27\u20130.81), but not magnesium sulfate (OR 0.82, 95% CI 0.48\u20131.40). In the subgroup that also received ritodrine (<jats:italic>n<\/jats:italic>\u2003=\u2003315), magnesium sulfate was given to 195 cases. In this group, the factor associated with an increased risk of combined adverse outcome (<jats:italic>n<\/jats:italic>\u2003=\u200364) after adjustment for the confounding effects was also corticosteroids (adjusted OR 0.25, 95% CI 0.13\u20130.49), but magnesium sulfate was not associated with an increase in risk (OR 0.64, 95% CI 0.34\u20131.22).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Long\u2010term tocolysis with magnesium sulfate is not a significant factor related to the occurrence of neonatal and infantile adverse outcomes. Further study is needed to clarify the dose\u2013response effect of magnesium sulfate.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01583.x","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T03:19:49Z","timestamp":1310008789000},"page":"1609-1614","source":"Crossref","is-referenced-by-count":7,"title":["Short\u2010 and long\u2010term outcomes in babies born after antenatal magnesium treatment"],"prefix":"10.1111","volume":"37","author":[{"given":"Minoru","family":"Mitani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Perinatal Research Network Group in Japan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.6.602"},{"key":"e_1_2_6_3_2","first-page":"369","article-title":"Long\u2010term tocolysis with combined intravenous terbutaline and magnesium sulfate: A 10\u2010year study of 1000 patients","volume":"84","author":"Kosasa TS","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","first-page":"373","article-title":"Long\u2010term tocolysis with intravenous magnesium sulfate","volume":"73","author":"Dudley D","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01409.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700128"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24047-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63935-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.123283"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91270-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birth weight infants?","volume":"95","author":"Nelson KB","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004661.pub3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292605"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80005-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2002.074"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.1995.03520290065031","article-title":"Effects of corticosteroids for fetal maturation on perinatal outcomes","volume":"273","author":"NIH Consensus Development Panel on the Effects of Corticosteroids for Fetal Maturation on Perinatal Outcomes","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0002-9378(13)90462-2","article-title":"Maternal and umbilical cord serum interleukin levels in preterm labor with clinical chorioamnionitis","volume":"170","author":"Lencki SG","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_18_2","first-page":"67","volume-title":"Perinatal Diseases. 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