{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:26:46Z","timestamp":1790839606059,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukemia during pregnancy is rare, posing a complex series of questions, including appropriate therapy and maternal counseling. Management of chronic myelocytic leukemia (CML) during pregnancy is limited. Our patient presented at 30\u2003weeks' gestation with anemia, leukocytosis, and a non\u2010productive cough. Polymerase chain reaction performed on a peripheral blood sample confirmed presence of the breakpoint cluster region\u2010Abl1 chromosomal translocation and the diagnosis of CML. Therapy included acute leukocytapheresis, followed by \u03b1\u2010interferon and imatinib mesylate. The patient responded to treatment and delivered a viable female infant at term weighing 2613\u2003g. Continued imatinib mesylate chemotherapy post\u2010delivery resulted in complete clinical remission. Successful antepartum management of newly diagnosed CML is possible utilizing leukocytapheresis, \u03b1\u2010interferon and, more recently, imatinib mesylate. Definitive treatment should not be delayed due to pregnancy.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01591.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T13:03:30Z","timestamp":1311685410000},"page":"1731-1733","source":"Crossref","is-referenced-by-count":11,"title":["Chronic myelocytic leukemia in pregnancy: A case report describing successful treatment using multimodal therapy"],"prefix":"10.1111","volume":"37","author":[{"given":"Ramez N.","family":"Eskander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tarsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199602000-00023"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.2084"},{"key":"e_1_2_4_4_2","first-page":"260","article-title":"Chromic myeloid leukemia in chronic phase responding to imatinib: The occurrence of additional cytogenetic abnormalities predicts disease progression","volume":"88","author":"Marktel S","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830380316"},{"key":"e_1_2_4_6_2","first-page":"338","article-title":"Pregnancy and leukemia","volume":"16","author":"Caligiuri MA","year":"1989","journal-title":"Semin Oncol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.9876"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1158\/1078-0432.12.11.1","article-title":"Food and Drug Administration Drug Approval Summary: Conversion of imatinib mesylate (STI571; Gleevec) tablets from accelerated approval to full approval","volume":"11","author":"Cohen MH","year":"2005","journal-title":"Clin Cancer Res"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-114900"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2011.01591.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2011.01591.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:49:39Z","timestamp":1697366979000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2011.01591.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,25]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1447-0756.2011.01591.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2011.01591.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,25]]}}}