{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:42:23Z","timestamp":1790502143696,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beckwith\u2013Wiedemann syndrome (BWS) is a common overgrowth syndrome that involves abdominal wall defects, macroglossia, and gigantism. It is sometimes complicated by placental tumor and polyhydramnios. We report a case of BWS, prenatally diagnosed with ultrasonography. A large and well\u2010circumscribed tumor also existed on the fetal surface of the placenta, which was histologically diagnosed as chorangioma after delivery. Polyhydramnios was obvious and the fetal heart enlarged progressively during pregnancy. Because the biophysical profiling score dropped to 4 points at 33\u2003weeks of gestation, we carried out cesarean section. By epigenetic analysis, H19\u2010differentially methylated region hypermethylation was observed in the placental tumor, normal placental tissue, and cord blood mononuclear cells. This is the first report of BWS with placental tumor due to H19\u2010differentially methylated region hypermethylation.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01654.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T13:14:45Z","timestamp":1317215685000},"page":"1872-1876","source":"Crossref","is-referenced-by-count":15,"title":["Beckwith\u2013Wiedemann syndrome with placental chorangioma due to H19\u2010differentially methylated region hypermethylation: A case report"],"prefix":"10.1111","volume":"37","author":[{"given":"Aiko","family":"Aoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihiro","family":"Shiozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Sameshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Higashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"316","article-title":"Exomphalos\u2010macroglossia\u2010gigantism syndrome in Jamaican infants","volume":"119","author":"Thorburn MJ","year":"1970","journal-title":"Am J Dis Child"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1209"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90237-J"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<145::AID-AJMG6>3.0.CO;2-V"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000298909"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819209023296"},{"key":"e_1_2_4_8_2","first-page":"1030","volume-title":"Obstetrical and Gynecological Pathology","author":"Fox H","year":"1987"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091506"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30267"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0794-433"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35013100"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/35013106"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2011.01654.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2011.01654.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T21:05:27Z","timestamp":1697317527000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2011.01654.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1447-0756.2011.01654.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2011.01654.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}