{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:45:54Z","timestamp":1774939554220,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this study was to examine the therapeutic effects of an ethinyl estradiol (EE) and desogestrel (DSG) combination pill in polycystic ovary syndrome (PCOS).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 42 women with PCOS were treated with an EE 30 mcg and DSG 150 mcg (EE\/DSG) combination pill for 12 cycles. The following parameters were studied at 0, 6, and 12\u2003months: body mass index, abdominal circumference, Ferriman\u2013Gallwey score, presence of acne and acanthosis nigricans, serum testosterone and sex\u2010hormone\u2010binding globulin levels, fasting glucose and fasting insulin levels. Free androgen index and glucose\u2003:\u2003insulin ratio were calculated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were significant improvements in Ferriman\u2013Gallwey score, incidence of acne, serum testosterone and sex\u2010hormone\u2010binding globulin levels and free androgen index values at the 6\u2010month follow up. But there were no further beneficial changes in the above parameters at the 12\u2010month follow up. There were no significant changes in body mass index, abdominal circumference, incidence of acanthosis nigricans, fasting glucose and insulin levels and glucose\u2003:\u2003insulin ratio during treatment.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Significant improvements in hyperandrogenic parameters were seen only in the first 6\u2003months of treatment with EE\/DSG in PCOS. Further continuation with this pill did not produce any significant improvement. There were no adverse effects on insulin sensitivity.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01682.x","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T04:29:28Z","timestamp":1320899368000},"page":"285-290","source":"Crossref","is-referenced-by-count":9,"title":["Effects of ethinyl estradiol and desogestrel on clinical and metabolic parameters in Indian patients with polycystic ovary syndrome"],"prefix":"10.1111","volume":"38","author":[{"given":"Sudhindra Mohan","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mainak","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105909"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.74.1.64"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2227"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00458-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903367002"},{"key":"e_1_2_6_9_2","first-page":"497","article-title":"Polycystic ovary syndrome: a diagnostic challenge","volume":"14","author":"Lewis V","year":"2003","journal-title":"Infert Reprod Med Clin North Am"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp033496"},{"key":"e_1_2_6_11_2","first-page":"1389","article-title":"Clinical management guidelines for obstetrician\u2010gynecologist: number 41","volume":"100","author":"Practice Bulletin ACOG","year":"2002","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00718-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00701.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.04.002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.02.009"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53212-9"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb01061.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.1.36"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.6.1816"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030328"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10583"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2011.01682.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2011.01682.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:44:41Z","timestamp":1727052281000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2011.01682.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,9]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1447-0756.2011.01682.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2011.01682.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,9]]}}}