{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:10:52Z","timestamp":1777529452796,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To clarify the alterations of myostatin, a member of the transforming growth factor\u2010\u03b2 superfamily, and follistatin\u2010like\u20033 (FSTL3), a binding protein for myostatin, in pre\u2010eclamptic women.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Samples of blood and placenta were collected from 40 pre\u2010eclamptic women and 40 controls. The serum level and placental expression of FSTL3 and myostatin were determined with enzyme\u2010linked immunosorbent assay, real\u2010time polymerized chain reaction and western blotting.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The serum levels of myostatin and FSTL3 were significantly higher in pre\u2010eclamptic women than in the controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 for both). Placental expression of myostatin and FSTL3 were also significantly increased in the pre\u2010eclamptic placenta compared with that of the controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 for both); however, there were no significant differences in myostatin or FSTL3 in either the maternal serum or the placenta in women with mild or severe pre\u2010eclampsia (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05 for both).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The serum levels and placental expression of myostatin and FSTL3 are elevated in pre\u2010eclampsia, suggesting the role of myostatin and its binding protein in pre\u2010eclampsia.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01823.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T03:39:40Z","timestamp":1336534780000},"page":"988-996","source":"Crossref","is-referenced-by-count":38,"title":["Alterations of maternal serum and placental follistatin\u2010like\u20033 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