{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:50:30Z","timestamp":1706770230920},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The best treatment option for cervical intraepithelial neoplasia 2 (CIN2) is controversial and there is a lack of studies in value\u2010based medicine. This multicenter comparative study was undertaken to evaluate the effectiveness, cost\u2010effectives and quality of life (QOL) of loop electrosurgical excision procedure (LEEP) and CO<jats:sub>2<\/jats:sub> laser vaporization for the treatment of CIN2.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> A database of LEEP and laser vaporizations performed at three research centers was created. Patients with colposcopic\u2010histopathologically confirmed CIN2 were randomly submitted to LEEP and laser vaporization. Cytology, human papilloma virus (HPV) DNA test and histology were performed, and a questionnaire on QOL was filled out during follow\u2010up. Effectiveness, cost\u2010effectives and QOL were analyzed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Three hundred and thirty\u2010eight women with CIN2 were included in the study. Frequencies of remission, and persistent and recurrent CIN were 89.2%, 7.2%, and 3.6% for LEEP, and 86.7%, 12.6%, 0.70% for laser, respectively. There was no significant difference in remission and persistence of CIN. There was a significant difference in the number of operations, recovery time and costs. Women treated with two methods showed relatively identical QOL.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Both LEEP and CO<jats:sub>2<\/jats:sub> laser vaporization are effective and reliable treatments for CIN2, whereas cervical tissue can be obtained for histology by LEEP. Preoperative evaluation and postoperative follow\u2010up are important. Gynecologists should pay attention to QOL of patients with CIN.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2011.01832.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T03:46:10Z","timestamp":1336535170000},"page":"1064-1070","source":"Crossref","is-referenced-by-count":9,"title":["Value\u2010based medicine analysis on loop electrosurgical excision procedure and CO<sub>2<\/sub> laser vaporization for the treatment of cervical intraepithelial neoplasia 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