{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:21:31Z","timestamp":1781706091287,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:00:00Z","timestamp":1335744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this study was to evaluate the effect of oral N\u2010acetylcysteine (NAC) administration as an adjuvant to clomiphene citrate (CC) on induction of ovulation outcomes in patients with polycystic ovary syndrome (PCOS).<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> In this placebo\u2010controlled double\u2010blind randomized clinical trial, 180 PCOS infertile patients were randomly divided into two groups for induction of ovulation. Patients in group 1 received CC 100\u2003mg\/d plus NAC 1.2\u2003g\/d and patients in group 2 received CC plus placebo for 5\u2003days starting at day 3 of the cycle. On the 12th day of the menstrual cycle in the presence of at least one follicle with an 18\u201320\u2010mm diameter in ultrasound evaluation, 10\u2003000\u2003U hCG was injected intramuscularly and timed intercourse was advised 36\u2003h after hCG injection. Serum \u03b2\u2010hCG level was measured on the 16th day after hCG injection.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The number of follicles &gt;18\u2003mm and the mean endometrial thickness on the day of hCG administration were significantly higher among the CC+NAC group (<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.001). The ovulation and pregnancy rates were also significantly higher in the CC+NAC group (<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.02 and 0.04, respectively). No adverse side\u2010effects and no cases of ovarian hyperstimulation syndrome were observed in the group receiving NAC.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> NAC as a safe and well\u2010tolerated adjuvant to CC for induction of ovulation can improve the ovulation and pregnancy rates in PCOS patients. 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