{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:29:39Z","timestamp":1773973779110,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:00:00Z","timestamp":1335744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold>The aim of this study was to compare the relative frequencies of endocervical glandular involvement (EGI), multicentricity, positive endocervical surgical margins (ESM) and positive vaginal surgical margins (VSM), and adenocarcinoma<jats:italic>in situ<\/jats:italic>of the cervix (AIS) between high\u2010grade and low\u2010grade squamous intraepithelial lesions (HSIL and LSIL, respectively).<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold>We identified 238 patients with squamous intraepithelial lesions\/cervical intraepithelial neoplasia (CIN) who were treated by loop electrocautery excision (LEEP) or conventional cold\u2010knife conization (CKC). A total of 223 (72 [32.3%] LSIL\/CIN I; 85 [38.1%] HSIL\/CIN II; 66 [29.6%] HSIL\/CIN III; and 151 [67.7%], HSIL\/CIN II\u2003+\u2003III) LEEP\/CKC slides were histologically reviewed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>The frequencies of EGI, positive ESM, and multicentricity were significantly higher in the HSIL\/CIN II\u2003+\u2003III group than in the LSIL\/CIN I group (<jats:italic>P<\/jats:italic>\u2003=\u20030.001, 0.001, and 0.025, respectively). Eighteen of the 72 (25%) LSIL\/CIN I patients, 44 of the 85 (51.8%) HSIL\/CIN II patients, and 60 of the 66 (90.9%) HSIL\/CIN III patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) showed EGI. In four of the 72 (5.6%) LSIL\/CIN I patients, 18 of the 85 (21.2%) HSIL\/CIN II patients, and 42 of the 66 (63.6%) HSIL\/CIN III patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.001), ESM was positive. Two of the 72 (2.8%) LSIL\/CIN I patients, seven of the 85 (8.2%) HSIL\/CIN II patients, and 11 of the 66 (16.7%) HSIL\/CIN III patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.016) were multicentric.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>The current study showed that EGI, positive ESM and multicentricity were more often associated with HSIL\/CIN II\u2003+\u2003III than with LSIL\/CIN I. Moreover, the frequencies of EGI, multicentricity, and positive ESM increased with increasing severity of the cervical lesion. This result may influence the preference for the type of surgical procedure used for patients with cytological diagnosis of HSIL.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01847.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T07:18:01Z","timestamp":1335770281000},"page":"1206-1210","source":"Crossref","is-referenced-by-count":13,"title":["Endocervical glandular involvement, positive endocervical surgical margin and multicentricity are more often associated with high\u2010grade than low\u2010grade squamous intraepithelial lesion"],"prefix":"10.1111","volume":"38","author":[{"given":"Gozde","family":"K\u0131r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat Hakan","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cumhur 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