{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:24:50Z","timestamp":1786685090259,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this study was to determine the role of serum and peritoneal interleukin (IL)\u20106, tumor necrosis factor (TNF)\u2010\u03b1 and glycodelin A levels as diagnostic markers of endometriosis in adolescent girls.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> The study encompassed 50 adolescent girls, aged 13\u201319\u2003years, after menarche and with chronic pelvic pain who qualified for diagnostic laparoscopy. The patients were allocated into two groups: group I (endometriosis group) consisted of subjects with diagnosed endometriosis (<jats:italic>n<\/jats:italic>\u2003=\u200333, 66%) and group II (control group) included those whose laparoscopic examinations revealed no evidence of endometriosis (<jats:italic>n<\/jats:italic>\u2003=\u200317, 34%). IL\u20106, TNF\u2010\u03b1 and glycodelin A concentrations in serum and peritoneal samples were assessed using commercially available human enzyme\u2010linked immunosorbent assay kits. The value of <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 was adopted as the level of statistical significance.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with the control group, adolescent girls with endometriosis had significantly higher peritoneal fluid levels of: IL\u20106 (525.10\u2003\u00b1\u20031168.53\u2003pg\/mL vs 62.96\u2003\u00b1\u200382.35\u2003pg\/mL), TNF\u2010\u03b1 (5.79\u2003\u00b1\u20035.60\u2003pg\/mL vs 1.68\u2003\u00b1\u20031.24\u2003pg\/mL) and glycodelin A (94.24\u2003\u00b1\u200360.97\u2003ng\/mL vs 53.52\u2003\u00b1\u200341.43\u2003ng\/mL). Peritoneal IL\u20106, TNF\u2010\u03b1 and glycodelin A provided a good method of discrimination between subjects with endometriosis and controls. Using cut\u2010off points for peritoneal fluid IL\u20106 (90.00\u2003pg\/mL), TNF\u2010\u03b1 (3.00\u2003pg\/mL) and glycodelin A (60.0\u2003ng\/mL), exceptionally high odds ratios (10.2; 14.6; 2.2) were obtained in the prediction of endometriosis in adolescents.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> At the cut\u2010off value of 3.00\u2003pg\/mL, peritoneal TNF\u2010\u03b1 can be a reliable screening marker for the prediction of endometriosis in adolescents, giving a 14.6\u2010fold higher probability of endometriosis detection in girls with chronic pelvic pain.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01860.x","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T09:43:25Z","timestamp":1336470205000},"page":"1245-1253","source":"Crossref","is-referenced-by-count":44,"title":["Selected cytokines and glycodelin A levels in serum and peritoneal fluid in girls with endometriosis"],"prefix":"10.1111","volume":"38","author":[{"given":"Agnieszka","family":"Drosdzol\u2010Cop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Skrzypulec\u2010Plinta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181dbdc61"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-3-14"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2008.12.005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200504000-00058"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000242953.94749.2b"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2003.09.008"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.01.005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-123"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2006.00373.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093121"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01816-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00609-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1355"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg321"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del419"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh312"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00535.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.158"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903159680"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.426"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00569.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.11.004"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.10.008"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000119091"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.05.001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302010000100022"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2012.01860.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2012.01860.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:15:30Z","timestamp":1697386530000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2012.01860.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,8]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1447-0756.2012.01860.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2012.01860.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,8]]}}}