{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:24:54Z","timestamp":1792628694592,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Despite known association of parental carriers of structural chromosomal rearrangements with a history of recurrent pregnancy loss (RPL), the possibility of having a miscarriage due to an unbalanced chromosomal aberration remains unknown. There has been limited research on the reproductive outcome of such couples. The present study was done to report the distribution of structural chromosome rearrangements in patients experiencing RPL and to describe subsequent pregnancy outcomes in the carriers.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Chromosomal analysis was performed on blood samples from 788 individuals with RPL and distribution of chromosomal anomalies was studied. In couples found to have chromosomal rearrangements, pregnancy outcomes were recorded over 2\u2003years. In the subsequent pregnancy, cytogenetic analysis was done on amniotic fluid (obtained at 16\u201320\u2003weeks), or on miscarriage specimens (in pregnancies that failed to continue).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Chromosomal rearrangements were identified in 6.8% (54\/788) cases (including 5.9% reciprocal translocations, 0.7% Robertsonian translocations, and 0.1% inversions). The risk of having a chromosomal aberration was not related to the number of previous miscarriages. Over the next 2\u2003years, two\u2010thirds of the 49 documented pregnancies resulted in a normal live birth, and one\u2010third miscarried. Most miscarriages (56.2%) were euploid, two were trisomic and 12.5% had an unbalanced translocation.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In couples with no other cause of RPL other than a structural chromosomal rearrangement, nearly two\u2010thirds are likely to have a normal outcome in subsequent pregnancy. Couples with pure abortion histories carry higher risk for cytogenetic abnormality than couples with normal children in addition to abortions.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01905.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T18:11:46Z","timestamp":1338833506000},"page":"113-120","source":"Crossref","is-referenced-by-count":59,"title":["Reproductive outcome of couples with recurrent miscarriage and balanced chromosomal abnormalities"],"prefix":"10.1111","volume":"39","author":[{"given":"Puneet Kaur","family":"Kochhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.38.1.29"},{"key":"e_1_2_7_3_2","first-page":"1449","article-title":"Chromosomal study in spontaneous abortuses","volume":"9","author":"Kajii T","year":"1979","journal-title":"Perinat Med"},{"key":"e_1_2_7_4_2","first-page":"549","article-title":"Cytogenetic studies in 100 couples with recurrent spontaneous abortions","volume":"32","author":"Ward BE","year":"1980","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33240-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90488-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129729"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46099-1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285393"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160412"},{"key":"e_1_2_7_11_2","first-page":"282","volume-title":"Chromosomes Today","author":"Bout A","year":"1981"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1957.tb01403.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90470-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.1976.03270040025023","article-title":"Cytogenetic studies in reproductive loss","volume":"236","author":"Schmidt R","year":"1976","journal-title":"J Am Med Assoc"},{"key":"e_1_2_7_15_2","first-page":"507","article-title":"Chromosome translocations in couples with multiple spontaneous abortions","volume":"34","author":"Michels VV","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.144.151"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320240214"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.014"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh172"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38735.459144.2F"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq089"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190115"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00179.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.6.463"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285027"},{"key":"e_1_2_7_26_2","first-page":"299","volume-title":"Human Embryonic and Fetal Death","author":"Lippman\u2010hand A","year":"1980"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38498.669595.8F"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273488"},{"key":"e_1_2_7_29_2","unstructured":"Royal College of Obstetricians and Gynaecologists.The investigation and treatment of couples with recurrent first\u2010trimester and second\u2010trimester miscarriages. 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