{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:34Z","timestamp":1760906974601},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Platinum is a milestone drug against gynecologic malignancies. The purpose of this retrospective study was to investigate the feasibility of replacing carboplatin with nedaplatin in patients who had developed a hypersensitivity reaction to carboplatin.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Fifteen patients with recurrent gynecologic cancer (12 ovarian, 1 fallopian tube, 1 endometrial and 1 cervical cancer) who had experienced a hypersensitivity reaction to carboplatin and a possible clinical indication for continuing treatment with platinum were treated with nedaplatin (80\u2003mg\/m<jats:sup>2<\/jats:sup>)\u2010containing regimen.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The total number of nedaplatin cycles given was 137 (range 1\u201329). Four (27%) patients developed hypersensitivity reactions on the second, second, fourth, and ninth administration, respectively. The severities of all the hypersensitivity reactions were grade 3 or less. The other 11 patients (73%) had no nedaplatin\u2010associated hypersensitivity reactions. The incidence of hypersensitivity reactions in the paclitaxel and nedaplatin group (three of four, 75%) was more frequent than the docetaxel and nedaplatin group (none of seven, <jats:italic>P<\/jats:italic>\u2003=\u20030.024). The objective response rate in eleven patients with measurable disease was 36% (complete response at 9% and partial response at 27%), and the disease control rate was 73% (stable disease at 36%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Nedaplatin\u2010associated hypersensitivity reactions are not rare in patients who developed allergic reactions to carboplatin. Retreatment of carboplatin\u2010allergic patients with nedaplatin cannot be recommended without careful consideration of the potential risks and benefits.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01917.x","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T09:30:45Z","timestamp":1339579845000},"page":"336-340","source":"Crossref","is-referenced-by-count":10,"title":["Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin"],"prefix":"10.1111","volume":"39","author":[{"given":"Takahide","family":"Arimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kawana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Tsukazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Kozuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Taketani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg036"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.389"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13718-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1141"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90489-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058160"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181a1bf2e"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6519"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1098"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00136.x"},{"key":"e_1_2_6_12_2","first-page":"695","article-title":"Phase II study of 254\u2010S (cis\u2010diammine glycolato platinum) for gynecological cancer","volume":"19","author":"Kato T","year":"1992","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_13_2","first-page":"885","article-title":"A phase II clinical study of cis\u2010diammine glycolato platinum, 254\u2010S, for cervical cancer of the uterus","volume":"19","author":"Noda K","year":"1992","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70134-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00066-0"},{"key":"e_1_2_6_17_2","first-page":"108","article-title":"A new rapid desensitization protocol for chemotherapy agents","volume":"21","author":"Gastaminza G","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_18_2","first-page":"731","article-title":"Successful desensitization protocol for patients with hypersensitivity reactions caused by carboplatin","volume":"37","author":"Nishio S","year":"2010","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181a418ff"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.042"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21168"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.028"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61465-2"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00541-9"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00178-1"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6331"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6513"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.04.019"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh323"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01217.x"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2012.01917.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2012.01917.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T01:53:33Z","timestamp":1697334813000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2012.01917.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,13]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1447-0756.2012.01917.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2012.01917.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,13]]}}}