{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:30:51Z","timestamp":1793370651438,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To evaluate the clinicopathological features, management, survival and prognostic factors of patients with Sertoli\u2010Leydig cell tumors of the ovary (SLCT) managed at a single institution.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> The clinical records of patients with Sertoli\u2010Leydig cell tumors of the ovary managed at the KK Women's and Children's Hospital, Singapore, between October 1998 and December 2008 were reviewed. Data of pathological features, treatment given and progress on follow\u2010up was studied.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Sertoli\u2010Leydig cell tumor of the ovary accounted for 1.3% of malignant ovarian neoplasms. The median age of the patient was 30\u2003years. The most common mode of presentation was with hormonal\u2010related symptoms (80%) in the form of secondary amenorrhea, irregular menses and features of virilization. Thirteen of the 15 patients underwent surgical staging and all were found to have stage\u2010I disease at the time of diagnosis. Ten patients with intermediate and poorly differentiated tumors received adjuvant bleomycin, etoposide and cisplatin (BEP) chemotherapy. Recurrent disease was detected in two patients (13.3%) during a median follow\u2010up of 63\u2003months, both of whom had poorly differentiated type of tumor. Both these patients underwent optimal debulking surgery followed by postoperative chemotherapy (BEP regimen). There were no disease \u2010elated deaths and all patients were under complete remission at the last follow\u2010up.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> As most Sertoli\u2010Leydig cell tumors of the ovary are seen in young women and detected while still in the early stages, a favorable outcome can be achieved by conservative surgery. Patients with moderate and poorly differentiated types of tumors benefit from adjuvant chemotherapy. Recurrences tend to occur early and are commonly seen in patients with poorly differentiated tumors.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01928.x","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T09:53:55Z","timestamp":1339581235000},"page":"305-310","source":"Crossref","is-referenced-by-count":48,"title":["Sertoli\u2010Leydig cell tumor of the ovary: Analysis of a single institution database"],"prefix":"10.1111","volume":"39","author":[{"given":"Rani Akhil","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Kuei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Nin","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwai Lam","family":"Yam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198508000-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<187::AID-CNCR2820480130>3.0.CO;2-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00957.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149692.21205.9c"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58564-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11345"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.18.6.9821198"},{"key":"e_1_2_6_9_2","first-page":"140","article-title":"Surgical management of Sertoli\u2010Leydig cell tumors of the ovary","volume":"7","author":"Metzinger DS","year":"2002","journal-title":"CME J Gynecol Oncol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00203.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.1005"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198406000-00001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198403000-00004"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1046"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80116-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2008.06.011"},{"key":"e_1_2_6_17_2","first-page":"113","article-title":"A rare case of hyperandrogenism: Bilateral Leydig cell tumor of the ovary","volume":"23","author":"Marcelino M","year":"2010","journal-title":"Acta Med Port"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.12.007"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(84)90026-X"},{"key":"e_1_2_6_20_2","volume-title":"Histological Typing of Ovarian Tumours. 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