{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:57Z","timestamp":1788872337478,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During pregnancy, and especially during labor, the maternal carbon dioxide level declines considerably. Maternal carbon dioxide levels show a close relation with fetal carbon dioxide levels. The latter affects fetal cerebral oxygenation by regulating cerebral blood flow and shifting the oxyhemoglobin dissociation curve. In addition, maternal hypocapnia appears to impair placental oxygen transfer. Thus, maternal hyperventilation may interfere with optimal fetal cerebral oxygenation. Here, we provide a brief overview of the literature relevant to this issue.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01944.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T07:14:43Z","timestamp":1341558883000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Maternal carbon dioxide level during labor and its possible effect on fetal cerebral oxygenation: Mini review"],"prefix":"10.1111","volume":"39","author":[{"given":"Takuji","family":"Tomimatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Kakigano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Mimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,6]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"3","article-title":"Maternal hyperventilation and the fetus","volume":"14","author":"Huch R","year":"1986","journal-title":"J Perinat Med"},{"key":"e_1_2_10_3_2","first-page":"107","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2010"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112443881"},{"key":"e_1_2_10_5_2","first-page":"1377","article-title":"Effects of maternal hyperventilation and oxygen inhalation during labor on fetal blood\u2010gas status","volume":"40","author":"Haruta M","year":"1988","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955753"},{"key":"e_1_2_10_7_2","first-page":"205","article-title":"Cerebral oxygenation of the fetus, newborn, and adult","volume":"8","author":"Jones MD","year":"1984","journal-title":"Semin Perinatol"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000246308.37154.ce"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198412000-00018"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1982.242.5.H862"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.3.358"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90045-F"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90639-8"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197404000-00007"},{"key":"e_1_2_10_15_2","first-page":"351","volume-title":"Handbook of Physiology, Section 3: The Respiratory System, Vol. IV, Gas Exchanges","author":"Longo LD","year":"1987"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb00404.x"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198006000-00002"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000169402.13435.09"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1982.242.5.H862"},{"key":"e_1_2_10_20_2","first-page":"199","volume-title":"Maternal\u2010Fetal Medicine","author":"Meschia G","year":"2004"},{"key":"e_1_2_10_21_2","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1152\/ajplegacy.1975.228.5.1497","article-title":"Uteroplacental blood flow during alkalosis in the sheep","volume":"228","author":"Buss DD","year":"1975","journal-title":"Am J Physiol"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197404000-00008"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.3.469"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0135"},{"key":"e_1_2_10_25_2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1542\/peds.95.6.868","article-title":"Carbon dioxide protects the perinatal brain from hypoxic\u2010ischemic damage: An experimental study in the immature rat","volume":"95","author":"Vannucci RC","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.12.036"},{"key":"e_1_2_10_27_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1152\/jappl.1990.68.3.1086","article-title":"Quantitation of cerebral blood volume in human infants by near\u2010infrared spectroscopy","volume":"68","author":"Wyatt JS","year":"1990","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199106010-00007"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200512000-00053"},{"issue":"4","key":"e_1_2_10_30_2","first-page":"CD000136","article-title":"Maternal oxygen administration for fetal distress","author":"Fawole B","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(69)90026-7"},{"key":"e_1_2_10_32_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0002-9378(80)90856-X","article-title":"Influence of maternal oxygen administration on the term fetus before labor","volume":"136","author":"Young DC","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.105"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15269.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90048-5"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91439-0"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.084"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000164474.03350.7c"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13152.x"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00306-1"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018375"},{"key":"e_1_2_10_42_2","first-page":"119","article-title":"The effect of carbon dioxide on Doppler flow velocity waveforms in the human fetus","volume":"17","author":"Potts P","year":"1992","journal-title":"J Dev Physiol"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90867-4"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91759-4"},{"key":"e_1_2_10_45_2","first-page":"590","volume-title":"Williams Obstetrics","author":"Cunningham FG","year":"2010"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70101-6"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.11.032"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1973.tb02189.x"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(96)02452-9"},{"key":"e_1_2_10_50_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/jappl.1976.41.2.197","article-title":"Uteroplacental blood flow during hyperthermia with and without respiratory alkalosis","volume":"41","author":"Oakes GK","year":"1976","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02910.x"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2012.01944.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2012.01944.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T01:55:31Z","timestamp":1697334931000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2012.01944.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,6]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1447-0756.2012.01944.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2012.01944.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,6]]}}}