{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:15:57Z","timestamp":1771463757452,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T00:00:00Z","timestamp":1344816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Retained placenta is an important cause of maternal mortality. The present study was aimed to determine the efficacy of umbilical injection of oxytocin as a treatment modality in this condition.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> This was a single\u2010center randomized controlled trial incorporating 58 women with retained placenta of more than 30\u2003min, equally distributed into two study arms of intra\u2010umbilical injection of oxytocin (50\u2003IU oxytocin diluted with normal saline [NS] to a total volume 30\u2003mL) and intra\u2010umbilical injection of NS (30\u2003mL). Primary outcome was expulsion of the placenta within 30\u2003min following intervention. All the data were analyzed on an intention\u2010to\u2010treat basis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The success rate in the intra\u2010umbilical oxytocin group was 51.72% compared to 20.69% in the control arm. This difference in the primary outcome was statistically significant with a <jats:italic>P<\/jats:italic>\u2010value\u2003&lt;\u20030.05 (<jats:italic>P<\/jats:italic>\u2003=\u20030.014) favoring intra\u2010umbilical oxytocin infusion with an efficacy rate of 1.5 and a number\u2010needed\u2010to\u2010treat of 3. The peripartum bleeding complications were more in the NS group with a statistically higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) requirement of extra oxytocin to control post\u2010partum bleeding. There were no differences between the two groups in respect to other secondary outcomes, such as post\u2010partum fever, antibiotic requirement and hospital stay.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Umbilical vein injection of 50\u2003IU oxytocin in 30\u2003mL of NS delivered effectively via the umbilical cord with milking in cases of retained placenta seems a simple and promising technique to reduce the incidence of a potentially morbid procedure and other complications.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2012.01974.x","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T01:51:20Z","timestamp":1344909080000},"page":"75-82","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of intra\u2010umbilical oxytocin in the management of retained placenta: A randomized controlled trial"],"prefix":"10.1111","volume":"39","author":[{"given":"Ajanta","family":"Samanta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir Ghosh","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallab Kumar","family":"Mistri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Animesh","family":"Naskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha Pratim","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arindam","family":"Pande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"863","article-title":"Prolonged third stage of labor: Morbidity and risk factors","volume":"77","author":"Combs CA","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_3_2","first-page":"734","article-title":"Midwifery practices in rural Punjab, India","volume":"93","author":"Gordon JE","year":"1965","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780108.x"},{"key":"e_1_2_6_5_2","unstructured":"PrendivllleWJ ElbourneD McDonaldS.Active versus expectant management of the third stage of labor (Cochrane Review). 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