{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:57:18Z","timestamp":1787014638095,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to evaluate the significance of maternal toxoplasmosis, rubella, cytomegalovirus (\n                      <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\n                      ) and herpes simplex virus (\n                      <jats:styled-content style=\"fixed-case\">TORCH<\/jats:styled-content>\n                      ) screening in cases of fetal growth restriction (\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      The medical records of women carrying fetuses with\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      who underwent\n                      <jats:styled-content style=\"fixed-case\">TORCH<\/jats:styled-content>\n                      screening over a 10\u2010year period were retrospectively reviewed for maternal and congenital\n                      <jats:styled-content style=\"fixed-case\">TORCH<\/jats:styled-content>\n                      infection. Women carrying fetuses with\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      routinely underwent serologic\n                      <jats:styled-content style=\"fixed-case\">TORCH<\/jats:styled-content>\n                      tests and systematic ultrasound evaluation for congenital abnormalities. If a congenital\n                      <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\n                      infection was suspected, amniotic fluid, placenta or neonatal urine was used for\n                      <jats:styled-content style=\"fixed-case\">CMV DNA<\/jats:styled-content>\n                      detection by polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 319 patients, no cases of maternal or congenital infection with toxoplasma, rubella, or herpes simplex virus were found. Conversely, six cases (1.8%) were diagnosed with congenital\n                      <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\n                      infection, two of which had no structural abnormalities other than\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A complete maternal\n                      <jats:styled-content style=\"fixed-case\">TORCH<\/jats:styled-content>\n                      screening for cases of\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      appears to be unnecessary. Although a maternal\n                      <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\n                      test can be considered, the incidence of congenital\n                      <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\n                      infection was found to be low in\n                      <jats:styled-content style=\"fixed-case\">FGR<\/jats:styled-content>\n                      cases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1447-0756.2012.02012.x","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T22:27:47Z","timestamp":1351549667000},"page":"653-657","source":"Crossref","is-referenced-by-count":37,"title":["Significance of maternal screening for toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus infection in cases of fetal growth restriction"],"prefix":"10.1111","volume":"39","author":[{"given":"Ryo","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syusaku","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Mitsuda","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"KleinJO RemingtonJS.Current concepts of infections of the fetus and newborn infant.Infectious Diseases of the Fetus and Newborn Infant4th edn.1995:1.","DOI":"10.1016\/B978-0-323-79525-8.00010-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197108000-00144"},{"key":"e_1_2_6_4_1","unstructured":"American College of Obstetricians and Gynecologists.Intrauterine growth restriction.Practice BulletinNo.12. 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