{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:08:58Z","timestamp":1773018538971,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>It has been well established that tumor\u2010associated macrophages (TAMs<\/jats:styled-content>) play a tumor promoting role in endometrial endometrioid adenocarcinoma (EEC<\/jats:styled-content>). But the association with TAMs<\/jats:styled-content> and sex hormone receptor expression, and progression of precancerous endometrial lesions in EEC<\/jats:styled-content> has been little reported.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>We used immunohistochemistry to examine the expression of CD<\/jats:styled-content>68, CD<\/jats:styled-content>34, vascular endothelial growth factor (VEGF<\/jats:styled-content>), estrogen receptor (ER<\/jats:styled-content>) and progesterone receptor (PR<\/jats:styled-content>) in 95 cases of EEC<\/jats:styled-content>, as well as 35 cases of endometrial hyperplasia (including 15 atypical hyperplasia, 10 complex hyperplasia and 10 simple hyperplasia). We also correlated TAMs<\/jats:styled-content> count with various clinicopathological factors, sex hormone receptor, and prognostic value in patients with EEC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified that TAMs<\/jats:styled-content> count increased linearly with disease progression (mean count per case at \u00d7200 magnification: simple hyperplasia, 6.30; complex hyperplasia, 11.20; atypical hyperplasia, 29.40; EEC<\/jats:styled-content> 55.81, respectively; P<\/jats:italic>\u2009<\u20090.001), that microvascular density (MVD) also increased accordingly (27.50, 30.20, 50.13 and 59.94, respectively; P<\/jats:italic>\u2009<\u20090.001). The expression of progesterone receptor, not of estrogen receptor, significantly decreased with disease progression (P<\/jats:italic>\u2009<\u20090.05). Moreover, histopathologic grades, International Federation of Gynecology and Obstetrics (FIGO<\/jats:styled-content>) stage (2009), depth of myometrial invasion, pelvic lymph node metastasis, lymphovascular space invasion, and expression of PR<\/jats:styled-content> and VEGF<\/jats:styled-content> were associated with TAMs<\/jats:styled-content> count (P<\/jats:italic>\u2009=\u20090.0001, P<\/jats:italic>\u2009=\u20090.004, P<\/jats:italic>\u2009=\u20090.0001, P<\/jats:italic>\u2009=\u20090.04, P<\/jats:italic>\u2009=\u20090.0001, P<\/jats:italic>\u2009=\u20090.0001, P<\/jats:italic>\u2009=\u20090.0001, respectively). Progesterone receptor expression was also associated with histopathologic grades, lymphovascular space invasion, VEGF<\/jats:styled-content> and high TAMs<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.035, P<\/jats:italic>\u2009=\u20090.022, P<\/jats:italic>\u2009=\u20090.014, P<\/jats:italic>\u2009=\u20090.001, respectively). The estimated 5\u2010year survival rate of patients with low TAMs<\/jats:styled-content> was significantly higher than those with high TAMs<\/jats:styled-content> (96.4% vs 69.8%, P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>TAMs<\/jats:styled-content> are potentially related to PR<\/jats:styled-content> loss and progression of precancerous endometrial lesions in EEC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1447-0756.2012.02036.x","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T02:22:15Z","timestamp":1351563735000},"page":"855-863","source":"Crossref","is-referenced-by-count":36,"title":["Tumor\u2010associated macrophages correlate with progesterone receptor loss in endometrial endometrioid adenocarcinoma"],"prefix":"10.1111","volume":"39","author":[{"given":"Xue\u2010feng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Jinan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong\u2010lan","family":"Tang","sequence":"additional","affiliation":[{"name":"Departments of Pathology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010gang","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Pathology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2010ming","family":"Shen","sequence":"additional","affiliation":[{"name":"Departments of Pathology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Jinan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Jinan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010qiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092969"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/435752a"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.11.023"},{"key":"e_1_2_7_5_1","first-page":"3335","article-title":"Correlation of histological localization of tumor\u2010associated 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