{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:48:49Z","timestamp":1770997729357,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the significance of the cord blood ischemia\u2010modified albumin (<jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>) level as a diagnostic marker for perinatal asphyxia and to determine the associations of <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> levels with the complexity of pregnancy and abnormal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler findings, regardless of perinatal asphyxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro\/placental ratio (<jats:styled-content style=\"fixed-case\">C\/P<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> was measured by means of commercially available <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> kits and was expressed as picomoles per milliliter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ischemia\u2010modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). They were higher in newborns with perinatal asphyxia as compared to healthy controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.015). The <jats:styled-content style=\"fixed-case\">C\/P<\/jats:styled-content> ratio\u2010pulsatility index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) showed a significant difference between normal and complicated pregnancies without perinatal asphyxia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> levels were significantly increased in cases with abnormal <jats:styled-content style=\"fixed-case\">C\/P<\/jats:styled-content> ratio\u2010PI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated cord blood <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> levels may be accepted as a useful marker in perinatal asphyxia. Abnormal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler examinations are associated with elevated <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> levels in complicated pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1447-0756.2012.02055.x","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T05:12:50Z","timestamp":1356153170000},"page":"663-671","source":"Crossref","is-referenced-by-count":20,"title":["Cord blood ischemia\u2010modified albumin: Is it associated with abnormal <scp>D<\/scp>oppler findings in complicated pregnancies and predictive of perinatal asphyxia?"],"prefix":"10.1111","volume":"39","author":[{"given":"Abdullah","family":"Kumral","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Okyay","sequence":"additional","affiliation":[{"name":"Division of 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