{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:03:47Z","timestamp":1791936227513,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T00:00:00Z","timestamp":1359936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The objective of this study was to explore the result of pretreatment and concomitant use of metformin with clomiphene citrate (CC<\/jats:styled-content>) and rFSH<\/jats:styled-content> for ovulation induction in clomiphene\u2010citrate\u2010resistant polycystic ovary syndrome (PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>This randomized controlled trial was done in the D<\/jats:styled-content>haka M<\/jats:styled-content>edical C<\/jats:styled-content>ollege and H<\/jats:styled-content>ospital and the I<\/jats:styled-content>nfertility C<\/jats:styled-content>are and R<\/jats:styled-content>esearch C<\/jats:styled-content>entre, D<\/jats:styled-content>haka, B<\/jats:styled-content>angladesh. A total of 165 infertile patients with CC<\/jats:styled-content>\u2010resistant PCOS<\/jats:styled-content> who attended for treatment were the target population for this study. Patients were divided into three groups: groups A<\/jats:styled-content> and B<\/jats:styled-content> were given metformin and group C<\/jats:styled-content> was the control. Along with metformin, group A<\/jats:styled-content> received CC<\/jats:styled-content> and group B<\/jats:styled-content> received rFSH<\/jats:styled-content>. G<\/jats:styled-content>roup C<\/jats:styled-content> was treated with only rFSH<\/jats:styled-content>. Metformin was given 1500\u2009mg daily for 4 weeks. Afterwards CC<\/jats:styled-content> or rFSH<\/jats:styled-content> were added for induction of ovulation along with metformin. Six ovulatory cycles were assessed. Treatment was terminated when there was no response with maximum dose of CC<\/jats:styled-content> and rFSH<\/jats:styled-content> or after six ovulatory cycles without pregnancy or after achieving pregnancy. A P<\/jats:italic>\u2010value of <0.5 was considered as significant.<\/jats:p><\/jats:sec>Results<\/jats:title>Ovulation (89.09%) and pregnancy (54.55%) rates were higher in group B<\/jats:styled-content>. Ovulation (74.55%) and pregnancy (29.09%) rates were also satisfactory in group C<\/jats:styled-content> but a dose of rFSH<\/jats:styled-content> requirement was significantly higher (P<\/jats:italic>\u2009=\u20090.000). In group A,<\/jats:styled-content> both ovulation and pregnancy rate were much lower than the other two groups (27.27% and 12.73%, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Use of metformin increases the response of ovulation\u2010inducing agents and can be used safely in PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1447-0756.2012.02072.x","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T04:35:33Z","timestamp":1360038933000},"page":"966-973","source":"Crossref","is-referenced-by-count":16,"title":["Pretreatment and co\u2010administration of oral anti\u2010diabetic agent with clomiphene citrate or rFSH<\/scp> for ovulation induction in clomiphene\u2010citrate\u2010resistant polycystic ovary syndrome"],"prefix":"10.1111","volume":"39","author":[{"given":"Mosammat Rashida","family":"Begum","sequence":"first","affiliation":[{"name":"Anwer Khan Modern Medical College (AKMMC) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeba","family":"Akhter","sequence":"additional","affiliation":[{"name":"Dhaka Medical College Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Ehsan","sequence":"additional","affiliation":[{"name":"Infertility Care and Research Centre (ICRC) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosammat Shahina","family":"Begum","sequence":"additional","affiliation":[{"name":"Infertility Care and Research Centre (ICRC) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Khan","sequence":"additional","affiliation":[{"name":"Infertility Care and Research Centre (ICRC) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.045"},{"key":"e_1_2_6_3_1","first-page":"2002","article-title":"More data still needed on efficacy, safety of metformin for PCOS. 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