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Here, we investigated the cortical activations associated with dynamic\u2010mechanical allodynia in an experimental human pain model by functional magnetic resonance imaging (fMRI). Large and stable areas of brush\u2010evoked allodynia were induced in 11 healthy subjects by topical capsaicin (2.5%, 30\u2003min) application following local heating (45\u2003\u00b0C for 5\u2003min), thus combining both physical and chemical sensitization. During the fMRI experiments, allodynia was rekindled by local heat application (40\u2003\u00b0C for 5\u2003min) immediately before the allodynia testing. Brushing the untreated forearm (control condition) led to activations of the contralateral primary somatosensory cortex (S1), contralateral parietal association cortex (PA), bilateral secondary somatosensory cortices (S2) and insula (contralateral). Brushing the allodynic skin was painful and the cortical responses were partially overlapping with those induced by the nonpainful brush stimulation. Additionally, the contralateral inferior frontal cortex (IFC) and the ipsilateral insula were activated. Direct comparison between nonpainful brushing and brush\u2010evoked allodynia revealed significant increases in blood oxygenation level\u2010dependent (BOLD) signals in contralateral S1, PA, IFC and bilateral S2\/insula during allodynia. This study highlights the importance of a cortical network comprising S1, PA, S2\/insula and IFC in the processing of dynamic\u2013mechanical allodynia in the human brain. Furthermore, it demonstrates that the combined heat\/capsaicin model can be used successfully in the exploration of brain processes underlying stimulus\u2010evoked pain.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2004.03437.x","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T17:54:31Z","timestamp":1088099671000},"page":"3211-3218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Neural activation during experimental allodynia: a functional magnetic resonance imaging study"],"prefix":"10.1111","volume":"19","author":[{"given":"Christian","family":"Maih\u00f6fner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schmelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Neund\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann O.","family":"Handwerker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.548"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf137"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-13-04207.1996"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7668"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7668"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.07.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.951"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/jn.1990.63.3.559","article-title":"Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval","volume":"63","author":"Chudler E.H.","year":"1990","journal-title":"J. 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