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Here we demonstrate a significant increase in the endogenous neuronal expression of galectin\u20101 mRNA in facial motoneurons after either a nerve resection or crush injury in mice. This increase in galectin\u20101 expression was due in part to the loss of target\u2010derived factor(s) as indicated by both the return of galectin\u20101 expression to control levels following target re\u2010innervation and the increase in galectin\u20101 expression after blockade of axonal transport by an interneuronal colchicine injection. Furthermore, interneuronal injections of glial\u2010derived neurotrophic factor into the uninjured nerve also increased galectin\u20101 mRNA expression within facial motoneurons suggesting that positive signals may also be involved in the regulation of galectin\u20101 expression. Galectin\u20101 null mutant mice showed an attenuated rate of functional recovery of whisking movement after a facial nerve crush.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2004.03802.x","type":"journal-article","created":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T09:30:44Z","timestamp":1101979844000},"page":"2872-2880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Galectin\u20101 in regenerating motoneurons"],"prefix":"10.1111","volume":"20","author":[{"given":"J.","family":"McGraw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T.","family":"McPhail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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