{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:30:50Z","timestamp":1791178250089,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The glycoproteins tenascin\u2010C (TNC) and tenascin\u2010R (TNR) are extracellular matrix proteins involved in the development, plasticity and repair of the nervous system. Altered expression patterns after nerve lesions in adult animals have suggested that these molecules influence axonal regeneration. To test this hypothesis, we investigated adult mice constitutively deficient in the expression of TNC, TNR or both, using the facial nerve injury paradigm. Quantitative analysis of vibrissal movements prior to nerve transection and repair (facial\u2013facial anastomosis) did not reveal genotype\u2010specific differences, and thus impacts of the mutations on motor function in intact animals. Two months after nerve repair, recovery of vibrissal whisking was poor in wild\u2010type mice, a typical finding after facial\u2013facial anastomosis in rodents. Differential effects of the mutations on whisking were found: recovery of function was worse in TNC\u2010deficient and better in TNR null mice compared with wild\u2010type littermates. In double\u2010knockout animals, vibrissal performance was insufficient, but to a lesser extent compared with TNC null mutant mice. Retrograde labelling of motoneurons in the same animals showed that similar numbers of motoneurons had reinnervated the whisker pads in all experimental groups precluding varying extents of motoneuron death and\/or axon regeneration failures as causes for the different outcomes of nerve repair. Our results provide strong evidence that TNC promotes and TNR impedes recovery after nerve lesion. These findings are of particular interest with regard to the scanty knowledge about factors determining success of regeneration in the peripheral nervous system of mammals.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2005.04424.x","type":"journal-article","created":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T13:56:58Z","timestamp":1130853418000},"page":"2171-2179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Opposite impacts of tenascin\u2010C and tenascin\u2010R deficiency in mice on the functional outcome of facial nerve repair"],"prefix":"10.1111","volume":"22","author":[{"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doychin N.","family":"Angelov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Morellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra","family":"Lenzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Skouras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Irintchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats","volume":"180","author":"Angelov D.N.","year":"2005","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00545.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530191100"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-16-06218.1998"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.03.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7367884"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-08-02638.1990"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10109"},{"key":"e_1_2_7_12_1","first-page":"357","article-title":"The peripheral nerve and the neuromuscular junction are affected in the tenascin\u2010C\u2010deficient mouse","volume":"44","author":"Cifuentes\u2010Diaz C.","year":"1998","journal-title":"Cell. Mol. Biol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1523\/JNEUROSCI.18-13-04953.1998","article-title":"Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes","volume":"18","author":"Culican S.M.","year":"1998","journal-title":"J. Neurosci."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03605.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.2.625"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19980201)280:2<152::AID-JEZ6>3.0.CO;2-N"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053507855"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1115"},{"key":"e_1_2_7_19_1","first-page":"117","article-title":"Local application of extracellular matrix proteins fails to reduce the number of axonal branches after varying reconstructive surgery on rat facial nerve","volume":"16","author":"Dohm S.","year":"2000","journal-title":"Restor. Neurol. Neurosci."},{"key":"e_1_2_7_20_1","first-page":"173","article-title":"The innervation of the mystacial region of the white mouse. A topographical study","volume":"142","author":"D\u00f6rfl J.","year":"1985","journal-title":"J. Anat."},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1523\/JNEUROSCI.22-16-07177.2002","article-title":"Impairment of 1\u2010type Ca2+ channel\u2010dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin\u2010C","volume":"22","author":"Evers M.R.","year":"2002","journal-title":"J. Neurosci."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050938"},{"key":"e_1_2_7_23_1","first-page":"422","volume-title":"Neuroglia.","author":"Faissner A.","year":"1995"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6594"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(03)00109-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01627.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb02764.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7774"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03877.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-07121.2002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.6.1475"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01218353"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04274.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217322"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00106-2"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0028709"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191554"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.5.1159"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01189813"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490280214"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01257247"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90293-P"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4519-03.2004"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-08-0759"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00003.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2003.11.004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1523\/JNEUROSCI.18-04-01465.1998","article-title":"Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin\u2010C, or fibroblast growth factor\u20105","volume":"18","author":"Moscoso L.M.","year":"1998","journal-title":"J. Neurosci."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.66.195"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90243-K"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00061-1"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1055"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4043-x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.08.007"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1139\/y04-068"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1234"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.10.1821"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80115-9"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90065-7"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(09)00450-3"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15753"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01971.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130905"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8040"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04245.1999"},{"key":"e_1_2_7_65_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.110.2.401","article-title":"Tenascin is accumulated along developing peripheral nerves and allows neurite outgrowth in vitro","volume":"110","author":"Wehrle B.","year":"1990","journal-title":"Development"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1163\/156853964X00030"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-01822.2000"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2005.04424.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2005.04424.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:52:46Z","timestamp":1696909966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2005.04424.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1111\/j.1460-9568.2005.04424.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04424.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"2005-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}