{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:27:01Z","timestamp":1791235621435,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The serotonin receptor 5\u2010HT<jats:sub>2C<\/jats:sub> agonist <jats:italic>m<\/jats:italic>\u2010chlorophenylpiperazine (mCPP) has been widely used to induce anxiety\u2010like states in animals and anxiety in humans. We here addressed the effect of an intraperitoneal injection of mCPP on the perception of tinnitus in a behavioural protocol based on an active avoidance paradigm. In control saline\u2010treated animals, mCPP did not change compound action potential audiograms or measurable tinnitus. In contrast, mCPP to animals demonstrating salicylate\u2010induced tinnitus exacerbated tinnitus perception by nearly twofold. We went on to test whether manipulation of the peripheral generator of tinnitus (i.e. the cochlea) could extinguish this exacerbated perception by applying the <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) antagonist 7\u2010chlorokynurenate (7\u2010CK) into cochlear fluids using a 7\u2010CK\u2010soaked Gelfoam ball placed on the round window of each of the animals' two ears. In addition to blocking the tinnitus induced by salicylate alone, 50\u2003\u00b5<jats:sc>m<\/jats:sc> of 7\u2010CK clearly abolished tinnitus in animals receiving salicylate and an injection of mCPP. The demonstration that cochlear NMDA receptor blockade abolishes the exacerbated perception of tinnitus is highly relevant in terms of treatment. In addition to psychotherapeutic treatment that may help to attenuate an individual's perception of tinnitus, targeting cochlear NMDA receptors represents a promising therapeutic strategy, even in depressed or chronically anxious patients.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2005.04436.x","type":"journal-article","created":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T00:02:18Z","timestamp":1233100938000},"page":"2675-2678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["<i>m<\/i>\u2010Chlorophenylpiperazine exacerbates perception of salicylate\u2010induced tinnitus in rats"],"prefix":"10.1111","volume":"22","author":[{"given":"Matthieu J.","family":"Guitton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Puel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145701002632"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050568"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00203-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00027-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215473"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000757"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(91)90033-K"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.102.6.811"},{"key":"e_1_2_7_12_1","first-page":"19","article-title":"An animal model of tinnitus: a decade of development","volume":"15","author":"Jastreboff P.J.","year":"1994","journal-title":"Am. 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