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Intraneuronal gene expression of cytochrome oxidase subunit\u2003I (COI), a metabolic index of neuronal activity, was increased in the subthalamic nucleus, substantia nigra pars reticulata and decreased in frontal cortical areas, but paradoxically unchanged in the striatum, globus pallidus, entopeduncular nucleus and ventrolateral thalamic nucleus. Neither preproenkephalin\u2003A nor preprotachykinin mRNA expression, markers of striatal projection neurons, were modified in the denervated striatal area despite 90% loss of dopamine (DA) terminals. Preproenkephalin\u2003A mRNA expression was however, decreased in the nondepleted striatal region, suggesting compensatory increase of dopamine tone from those spared areas. A chronic treatment with the metabotropic glutamate receptor\u20035 (mGluR5) antagonist 2\u2010methyl\u20106\u2010(phenylethylnyl)\u2010pyridine (MPEP), which alleviated the akinetic disorders produced by the lesion, reversed the lesion\u2010induced variations of COI gene expression, moderately increased this marker in the structures unaffected by the lesion and did not modify the striatal neuropeptides gene expression. These data suggest that the expression of akinetic deficits in early parkinsonism is associated with focused metabolic changes in the cortico\u2010basal ganglia\u2010cortical loop downstream of the striatum and pallidal complex.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2005.04498.x","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T14:41:26Z","timestamp":1133275286000},"page":"2765-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Dysfunction of the cortico\u2010basal ganglia\u2010cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor\u20035 antagonism"],"prefix":"10.1111","volume":"22","author":[{"given":"Abid","family":"Oueslati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Breysse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Amalric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kerkerian\u2010Le Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Salin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199508000-00011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01085.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07871.2000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03792.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06531.1995"},{"key":"e_1_2_7_7_1","first-page":"S40","article-title":"Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: methodologic aspects and clinical criteria","volume":"55","author":"Benabid A.L.","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02235-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00006-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.1523\/JNEUROSCI.23-23-08302.2003","article-title":"Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal\u2010ganglia structures in parkinsonian rats","volume":"23","author":"Breysse N.","year":"2003","journal-title":"J. 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