{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:55:10Z","timestamp":1792097710504,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effectiveness of hypothermia in preventing ischemic brain damage depends on when it is started. The purpose of this study was to investigate the effects of temperature reduction during a hypoxic\u2013ischemic (HI) insult on brain injury and signalling pathways of neuronal cell death and survival. Seven\u2010day\u2010old mice were subjected to left common carotid artery ligation and hypoxia (10% oxygen) at different temperatures (37, 36 or 34\u2003\u00b0C) for 50\u2003min. Brain injury at 7\u2003days post\u2010HI was significantly reduced from 67.4% at 37\u2003\u00b0C to 31.6% at 36\u2003\u00b0C and 10% at 34\u2003\u00b0C, with no observable injury in the cortex of the 34\u2003\u00b0C group. Cytochrome\u2003c release, caspase\u20103 activation and apoptosis\u2010inducing factor translocation from mitochondria to nuclei were all significantly inhibited after intraischemic temperature reduction. Concurrently, the cell survival signalling pathway involving Akt was significantly sustained (the phosphorylated form of Akt was maintained) when the hypoxia temperature was decreased. These results indicate that intraischemic hypothermia diminished apoptosis through inhibition of both caspase\u2010dependent and caspase\u2010independent neuronal cell death pathways and promoted cell survival by inhibition of phosphorylated Akt dephosphorylation in the neonatal brain, thereby preventing neuronal cell death.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2005.04581.x","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T20:37:05Z","timestamp":1137616625000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia\u2013ischemia"],"prefix":"10.1111","volume":"23","author":[{"given":"Changlian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Simbruner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klas","family":"Blomgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007807200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03982.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.904"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1318"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740655"},{"key":"e_1_2_7_9_1","first-page":"177","article-title":"Brain damage and temperature: cellular and molecular mechanisms","volume":"71","author":"Dietrich W.D.","year":"1996","journal-title":"Adv. Neurol."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00649.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9950129"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000066287.21705.21"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03313.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02659-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199802000-00014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02547.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200009000-00003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858402008003007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199601000-00012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1095-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1103"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0513"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.1.0090"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2003.08.018"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91201-B"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200112000-00009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.065"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2000.00346.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30405-6"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.377"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-837265"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.4.571"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02178-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00036-9"},{"key":"e_1_2_7_40_1","first-page":"330","article-title":"Mechanisms of perinatal hypoxic\u2010ischemic brain damage","volume":"17","author":"Vannucci R.C.","year":"1993","journal-title":"Semin. Perinatol."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.2.245"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047087"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.01.014"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90024-X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00386-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200201000-00003"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-7516(99)00040-X"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.232"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200201000-00004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02220-X"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00247-9"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600111"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01832.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.10.013"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401545"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2005.04581.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2005.04581.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:05:43Z","timestamp":1696871143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2005.04581.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1460-9568.2005.04581.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04581.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}