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The development of mechanical and thermal allodynia, as well as thermal hyperalgesia was evaluated by using the von Frey filament model, the cold\u2010plate test and the plantar test, respectively. In wild\u2010type and DOR knockout mice, sciatic nerve injury led to a neuropathic pain syndrome revealed in these nociceptive behavioural tests. However, the development of mechanical and thermal allodynia, and thermal hyperalgesia was significantly enhanced in DOR knockout mice. These results reveal the involvement of DOR in the control of neuropathic pain and suggest a new potential therapeutic use of DOR agonists.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04569.x","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T07:55:35Z","timestamp":1140162935000},"page":"830-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Neuropathic pain is enhanced in \u03b4\u2010opioid receptor knockout mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Xavier","family":"Nadal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep\u2010Eladi","family":"Ba\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte L.","family":"Kieffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90198-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X97221485"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.12"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/76061"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703248"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1523\/JNEUROSCI.14-08-04965.1994","article-title":"Inhibitory actions of delta 1\u2010, delta 2\u2010, and mu\u2010opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord","volume":"14","author":"Glaum S.R.","year":"1994","journal-title":"J. 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