{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:52:55Z","timestamp":1761580375007},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T00:00:00Z","timestamp":1140048000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extent of re\u2010growth of catecholaminergic fibers, the survival of cholinergic neurons and the degree of autonomic dysreflexia were assessed in complete spinal cord\u2010transected adult rats that received a repair treatment of peripheral nerve grafts and acidic fibroblast growth factor (aFGF). The rats were randomly divided into three groups: (1) sham control group (laminectomy only); (2) spinal cord transection at T8 (transected group); and (3) spinal cord transection at T8, followed by aFGF treatment and peripheral nerve graft (repaired group). The spinal cords and brains of all rats were collected at 6\u2003months post\u2010surgery. Immunohistochemistry for tyrosine hydroxylase (TH) and dopamine\u2010\u03b2\u2010hydroxylase (DBH), and fluoro\u2010gold (FG) retrograde tracing were used to evaluate axon growth across the damage site, and immunocytochemistry for choline acetyl transferase (ChAT) was used to evaluate cholinergic neuronal cell survival following the injury and treatment. When comparing with the transected group, the repaired group showed: (1) lower elevation of mean arterial pressure during colorectal distension; (2) retrogradely labeled neurons in the hypothalamus, zona incerta, subcoeruleus nuclei and rostral ventrolateral medulla following application of FG below the repair site; (3) the presence of TH\u2010 and DBH\u2010labeled axons below the lesion site; (4) higher numbers of ChAT\u2010positive neurons in ventral horn and intermediolateral column near the lesion site. We conclude that peripheral nerve graft and aFGF treatments facilitate the re\u2010growth of catecholaminergic fibers, also protect sympathetic preganglionic neurons and spinal motor neurons, and reduce autonomic dysfunction in a T\u20108 spinal cord\u2010transected rat model.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04598.x","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T07:55:35Z","timestamp":1140162935000},"page":"693-702","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Re\u2010growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats"],"prefix":"10.1111","volume":"23","author":[{"given":"Yu\u2010Shang","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon W.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150252932433"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7119"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7413"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01406.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2003.08.0055"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00599-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902720410"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5274.510"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01405432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1523\/JNEUROSCI.17-10-03710.1997","article-title":"Purkinje cell survival and axonal regeneration are age dependent: an in vitro study","volume":"17","author":"Dusart I.","year":"1997","journal-title":"J. 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