{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:50:17Z","timestamp":1791039017848,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitochondrial dysfunction has been implicated in the death of nigrostriatal dopaminergic neurons in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010treated experimental models of Parkinson's disease (PD). Here we utilized proton magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H MRS) to identify changes in energy metabolism in the striatum of MPTP\u2010treated C57BL\/6 mice. Remarkable increases in lactate\/creatine (Lac\/Cr) ratio were observed at 2\u2003h and then quickly returned to about the basal level by 7\u2003h after injection of MPTP. Neurochemical and Western blot analyses revealed that dopamine contents and protein levels of tyrosine hydroxylase and dopamine transporter in the striatum were profoundly decreased at 3\u2003days after MPTP treatment. Pretreatment with deprenyl, a monoamine oxidase B inhibitor, or GBR\u201012909, a dopamine uptake inhibitor, almost completely attenuated both the increases in striatal Lac\/Cr ratio and the subsequent loss of dopaminergic nerve terminals in MPTP\u2010treated mice. The present study indicates that <jats:sup>1<\/jats:sup>H MRS is a sensitive measure of biochemical alterations of the brain in a mouse model of PD, and further shows that the increases in striatal Lac\/Cr ratio induced by MPTP may be associated with mitochondrial energy crisis, followed by dopaminergic neurotoxicity.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04610.x","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T11:39:14Z","timestamp":1139398754000},"page":"1077-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["<sup>1<\/sup>H MRS identifies lactate rise in the striatum of MPTP\u2010treated C57BL\/6 mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Keiko","family":"Koga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Mitsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4364-04.2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/3300"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.438"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01291788"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90084-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6610213"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/311467a0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370608"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2.117"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.7.2173"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199605000-00011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823561"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/70978"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.6.672"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90346-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.11.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8056"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90146-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(02)00015-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4565"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1016\/S0021-9258(19)57434-8","article-title":"Energy\u2010dependent uptake of N\u2010methyl\u20104\u2010phenylpyridinium, the neurotoxic metabolite of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine, by mitochondria","volume":"261","author":"Ramsay R.R.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.2019"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90986-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb13610.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/373335a0"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2006.04610.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2006.04610.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:09:58Z","timestamp":1696874998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2006.04610.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1460-9568.2006.04610.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04610.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"2006-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}