{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:25:59Z","timestamp":1771993559190,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early neural activity, both prenatal spontaneous bursts and early visual experience, is believed to be important for dendritic proliferation and for the maturation of neural circuitry in the developing retina. In this study, we have investigated the possible role of early neural activity in shaping developing turtle retinal ganglion cell (RGC) dendritic arbors. RGCs were back\u2010labelled from the optic nerve with horseradish peroxidase (HRP). Changes in dendritic growth patterns were examined across development and following chronic blockade or modification of spontaneous activity and\/or visual experience. Dendrites reach peak proliferation at embryonic stage\u200325 (S25, one week before hatching), followed by pruning in large field RGCs around the time of hatching. When spontaneous activity is chronically blocked <jats:italic>in vivo<\/jats:italic> from early embryonic stages (S22) with curare, a cholinergic nicotinic antagonist, RGC dendritic growth is inhibited. On the other hand, enhancement of spontaneous activity by dark\u2010rearing (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b12\">Sernagor &amp; Grzywacz (1996)<\/jats:ext-link><jats:italic>Curr. Biol.<\/jats:italic>, <jats:bold>6<\/jats:bold>, 1503\u20131508) promotes dendritic proliferation in large\u2010field RGCs, an effect that is counteracted by exposure to curare from hatching. We also recorded spontaneous activity from individual RGCs labelled with lucifer yellow (LY). We found a tendency of RGCs with large dendritic fields to be spontaneously more active than small\u2010field cells. From all these observations, we conclude that immature spontaneous activity promotes dendritic growth in developing RGCs.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04933.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T12:06:16Z","timestamp":1155557176000},"page":"773-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early neural activity and dendritic growth in turtle retinal ganglion cells"],"prefix":"10.1111","volume":"24","author":[{"given":"Vandana","family":"Mehta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Sernagor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390110"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-20-07672.2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/364144a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07037.1995"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02851.2003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5265.1182"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800172050"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1982.0087"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000411"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91471-P"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0172-05.2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3344435"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1406"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00850"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-17-07639.2002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-22-09928.1999"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80239-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04971.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2035024"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7223"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-05-01440.1991"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511541629.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000515)420:4<512::AID-CNE8>3.0.CO;2-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000515)420:4<527::AID-CNE9>3.0.CO;2-I"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80012-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960819)372:2<167::AID-CNE1>3.0.CO;2-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3603038"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-11-04239.1988"},{"key":"e_1_2_7_31_1","first-page":"1479","article-title":"Developmental neurotransmitters \u2013 Signals for shaping neuronal circuitry","volume":"37","author":"Redburn D.A.","year":"1996","journal-title":"Inv. Ophthal. Vis. Sci."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4876-04.2005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.03.010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511541629.015"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(00)00024-0"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.4.1355"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(96)00755-5"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-03874.1999"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2001.19940375.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-20-07621.2003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1800-05.2005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00389-1"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.5.1645"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800008609"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.2.447"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740650"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902940109"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.29"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-13-05024.2000"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn941"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480220704"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00059-8"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/85987"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903290209"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470920"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.015"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2006.04933.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2006.04933.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2006.04933.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1460-9568.2006.04933.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2006.04933.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:03:37Z","timestamp":1693573417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2006.04933.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1460-9568.2006.04933.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04933.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}