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In order to better understand signalling adaptations at the molecular level, we used high\u2010density oligonucleotide microarrays (Codelink Mouse 20K) to define alterations in the expression of transcripts encoding regulator of G\u2010protein coupled receptor signalling in dopamine D<jats:sub>1<\/jats:sub> receptor knockout mice (<jats:italic>Drd1a<\/jats:italic>\u2010KO). Regulator of G\u2010protein signalling (<jats:italic>Rgs<\/jats:italic>) <jats:italic>2<\/jats:italic>, <jats:italic>Rgs4<\/jats:italic>, and <jats:italic>Rgs9<\/jats:italic> were significantly decreased in the striatum (STR) of <jats:italic>Drd1a<\/jats:italic>\u2010KO mice. These changes were confirmed by <jats:italic>in situ<\/jats:italic> hybridization, and were also observed in the nucleus accumbens (NAc). In contrast, analysis of the medial frontal cortex (MFC) revealed a significant decrease in <jats:italic>Rgs17<\/jats:italic> expression exclusively, and a modest up\u2010regulation of <jats:italic>Rgs5<\/jats:italic> transcript. The expression of these gene products were not significantly altered in the dopamine\u2010poor visual cortex (VC). The <jats:italic>Drd1a<\/jats:italic>\u2010KO mouse, and a rabbit model of <jats:italic>in utero<\/jats:italic> cocaine exposure, in which D<jats:sub>1<\/jats:sub>R signalling is permanently reduced, possess analogous morphological and functional alterations in dopamine\u2010modulated brain circuits; thus we also examined long\u2010lasting changes in RGS transcript expression following prenatal exposure to cocaine. In sharp contrast to the <jats:italic>Drd1a<\/jats:italic>\u2010KO, <jats:italic>Rgs2<\/jats:italic> and <jats:italic>Rgs4<\/jats:italic> were unchanged, and <jats:italic>Rgs9<\/jats:italic> and <jats:italic>Rgs17<\/jats:italic> transcripts were increased in prenatal cocaine\u2010exposed progeny. These data suggest that an absolute absence of D<jats:sub>1<\/jats:sub>R signalling (<jats:italic>Drd1a<\/jats:italic>\u2010KO) and hypomorphic D<jats:sub>1<\/jats:sub>R signalling (prenatal cocaine) produce common alterations in neuronal morphology, but distinct outcomes in molecular neuroadaptations.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04970.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T12:06:16Z","timestamp":1155557176000},"page":"806-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Genetic or pharmacological inactivation of the dopamine D<sub>1<\/sub> receptor differentially alters the expression of regulator of G\u2010protein signalling (Rgs) transcripts"],"prefix":"10.1111","volume":"24","author":[{"given":"Gregg D.","family":"Stanwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua P.","family":"Parlaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Levitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002100100404"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00623-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0518"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.721529.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70052216.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244427"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00598-K"},{"key":"e_1_2_7_10_1","first-page":"209","article-title":"Effects of dopamine D\u20101 and D\u20102 antagonists on cocaine self\u2010administration under different schedules of reinforcement in the rat","volume":"270","author":"Caine S.B.","year":"1994","journal-title":"J. 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