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Although tonic GABA<jats:sub>A<\/jats:sub> receptor\u2010mediated currents have been well characterized in rodents, their existence in human tissue has yet to be demonstrated. Here we show that tonic currents can be recorded from human tissue obtained from patients undergoing temporal lobectomies. Tonic GABA<jats:sub>A<\/jats:sub> receptor\u2010mediated currents were present in pyramidal cells and interneurons in layer V\u2010VI of temporal neocortex and granule cells in the dentate gyrus. These tonic currents have cell type\u2010specific pharmacologies, opening up the possibility of targeted therapeutics.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04989.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T14:50:44Z","timestamp":1156863044000},"page":"1157-1160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Tonic GABA<sub>A<\/sub> receptor\u2010mediated currents in human brain"],"prefix":"10.1111","volume":"24","author":[{"given":"Annalisa","family":"Scimemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost H.","family":"Heeroma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Rydenhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Thom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Asztely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.4.814"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1703"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.1996.sp021806","article-title":"Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors","volume":"497","author":"Brickley S.G.","year":"1996","journal-title":"J. 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