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Differential screening of a rat spinal cord expression library was performed using polyclonal antibodies raised against lesioned spinal cord tissue. A striking overexpression was found for <jats:italic>ahnak<\/jats:italic>, encoding a 700\u2010kDa protein, in normal CNS present only in the blood\u2013brain barrier (BBB) forming vascular endothelial cells. Indeed, very early after spinal cord injury (SCI), high levels of membrane\u2010associated AHNAK are observed on non\u2010neuronal cells invading the lesion site. With time, AHNAK distribution spreads rostrally and caudally concomitant with the process of tissue inflammation and axon degeneration, delineating the interior surface of cystic cavities, mainly in front of barrier\u2010forming astrocytes. Strong overexpression is also observed on vascular endothelial cells reacting to BBB breakdown. Based on our detailed analysis of its spatiotemporal and cellular expression, and its previously described function in BBB, we suggest that AHNAK expression is associated with cell types displaying tissue\u2013protective barrier properties. Our study may thus contribute to the elucidation of the precise molecular and cellular events that eventually render traumatic spinal cord tissue non\u2010permissive for regeneration.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04994.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T14:50:44Z","timestamp":1156863044000},"page":"1031-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Spinal cord injury\u2010induced up\u2010regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ysander","family":"Von 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