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Although mutations in the nyctalopin gene (<jats:italic>NYX<\/jats:italic>) in humans lead to congenital stationary night blindness (CSNB1), affecting synaptic transmission between both types of photoreceptors and ON\u2010bipolar cells, the function of nyctalopin in cone\u2010dominant animal models has not been studied. Because the larval zebrafish retina is cone\u2010dominant, we isolated the zebrafish <jats:italic>nyx<\/jats:italic> ortholog and raised a polyclonal antibody against the protein. Nyctalopin is expressed postsynaptically in both synaptic layers of the retina. Functional disruption via morpholino antisense injection leads to characteristic defects in the electroretinogram and defects in visual contrast sensitivity. We therefore demonstrated that nyctalopin plays a similar role in retinal synapse function in the cone pathway as in the rod pathway, thereby creating a genetic model for CSNB1 and its effects on cone vision.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05053.x","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T08:57:43Z","timestamp":1158829063000},"page":"1664-1674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina"],"prefix":"10.1111","volume":"24","author":[{"given":"Ronja","family":"Bahadori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Biehlmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Zeitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Labhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri V.","family":"Makhankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gesemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan C. 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