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Mechanical allodynia was observed at 3\u2003days after ION\u2010CCI and lasted more than 14\u2003days. Single\u2010unit activities were recorded from the ION of anesthetized rats. C\u2010, A\u03b2\u2010 and A\u03b4\u2010units were identified on the basis of their conduction velocity. A\u03b4\u2010units were frequently encountered at a later period after ION\u2010CCI. The highest A\u03b4\u2010spontaneous activity was recorded at 3\u2003days after ION\u2010CCI and progressively decreased after that, but spontaneous activity was still higher at 14\u2003days after ION\u2010CCI than that of na\u00efve rats. Mechanical\u2010evoked responses of A\u03b4\u2010units were also highest at 3\u2003days after ION\u2010CCI and then gradually decreased. In consideration of these data, patch\u2010clamp recordings were performed on medium to large size neurons of the dissociated trigeminal ganglion (TRG). Patch\u2010clamp recordings revealed that the <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub> (sustained) and <jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub> (transient) in rats with ION\u2010CCI were significantly smaller than those of na\u00efve rats, and correlated with an increase in duration of repolarization phase and a decrease in duration of depolarization phase, respectively. The hyperpolarization\u2010activated current (<jats:italic>I<\/jats:italic><jats:sub>h<\/jats:sub>) was significantly larger in TRG neurons of rats with ION\u2010CCI as compared with those of na\u00efve rats. The present results suggest that <jats:italic>I<\/jats:italic><jats:sub>h<\/jats:sub>, <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub> and <jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub> in A\u03b4\u2010afferent neurons in TRG are significantly involved in the changes in afferent spontaneous activity and mechanically evoked activity that accompany mechanical allodynia produced by trigeminal nerve injury.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05065.x","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T20:27:14Z","timestamp":1160857634000},"page":"1976-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy"],"prefix":"10.1111","volume":"24","author":[{"given":"Junichi","family":"Kitagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kadoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniya","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.644"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90198-4"},{"key":"e_1_2_7_4_1","first-page":"201","volume-title":"Textbook of Pain","author":"Bennett G.J.","year":"1994"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00272-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771503767168519"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90343-R"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00275-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00169-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.11.044"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-6-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.09.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.2.700"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp018932"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90339-B"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.6.2629"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(90)90385-F"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1152\/jn.1990.64.5.1537","article-title":"Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy","volume":"64","author":"Guilbaud G.","year":"1990","journal-title":"J. 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