{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:55:52Z","timestamp":1774868152977,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cajal\u2013Retzius cells are implicated in regulating neuronal migration and lamination during corticogenesis. In rodents, Cajal\u2013Retzius cells are transient, being prevalent in the marginal zone of the embryonic neocortex and declining over the first two postnatal weeks. While studies have examined in postnatal neocortex the properties of GABA<jats:sub>A<\/jats:sub> receptors in Cajal\u2013Retzius cells, less is known about their disposition at embryonic stages. Here, we combined patch\u2010clamp electrophysiology and single\u2010cell mRNA profiling to probe the expression of GABA<jats:sub>A<\/jats:sub> receptors in Cajal\u2013Retzius cells. In embryonic neocortical slices, GABA elicited GABA<jats:sub>A<\/jats:sub> receptor\u2010mediated current responses that were diazepam\u2010insensitive and inhibited by Zn<jats:sup>2+<\/jats:sup>, a pharmacological profile consistent with expression of \u03b3\u2010less GABA<jats:sub>A<\/jats:sub> receptor isoforms. Non\u2010Cajal\u2013Retzius cells in the same embryonic slices, on the other hand, were robustly potentiated by diazepam and were insensitive to Zn<jats:sup>2+<\/jats:sup>, typical of \u03b3\u2010containing GABA<jats:sub>A<\/jats:sub> receptor isoforms, as were Cajal\u2013Retzius cells in the postnatal neocortex. Single\u2010cell mRNA profiling and immunohistochemistry confirmed expression of GABA<jats:sub>A<\/jats:sub> receptor \u03b3 subunit transcript and protein, respectively, in individual reelin\u2010expressing cells in the postnatal cortex but not in their embryonic counterparts. We conclude that Cajal\u2013Retzius cells express \u03b3\u2010less GABA<jats:sub>A<\/jats:sub> receptors at embryonic stages and switch to expressing \u03b3\u2010containing GABA<jats:sub>A<\/jats:sub> receptor isoforms during postnatal neocortical development.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05122.x","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T16:22:50Z","timestamp":1161706970000},"page":"2145-2151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cajal\u2013Retzius cells switch from expressing \u03b3\u2010less to \u03b3\u2010containing GABA<sub>A<\/sub> receptors during corticogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"Qing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela W. 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