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After a crush injury of sciatic nerves, dorsal roots or dorsal column in adult Sprague\u2013Dawley rats, the immunoreactivity for pro\u2010BDNF accumulated at both the proximal and distal segments. The accumulation reached a maximum at 24\u2003h after injury. Western blot analysis also revealed pro\u2010BDNF in sciatic nerve segments proximal and distal to the ligature and in the spinal cord. Biotinylated or Alexa\u2010488\u2010labelled pro\u2010BDNF injected into sciatic nerve was internalized and transported both retrogradely and anterogradely within sensory neurons. These results demonstrate that pro\u2010BDNF is anterogradely and retrogradely transported in sensory neurons, suggesting that endogenous pro\u2010BDNF may be released and play important functions.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05138.x","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T17:42:45Z","timestamp":1163439765000},"page":"2444-2452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Axonal transport of BDNF precursor in primary sensory neurons"],"prefix":"10.1111","volume":"24","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Lin\u2010yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Yun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Gang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Fu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/39885"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10315"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:24:1-3:001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01005-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90023-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1017-05.2005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0348-04.2004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00449-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90213-W"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6139-5_22"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80542-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00397-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-24-07950.1996"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480251109"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90536-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"6123","DOI":"10.1523\/JNEUROSCI.23-14-06123.2003","article-title":"Inhibitory but not excitatory cortical neurons require presynaptic brain\u2010derived neurotrophic factor for dendritic development, as revealed by chimera cell culture","volume":"23","author":"Kohara K.","year":"2003","journal-title":"J. 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