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The general effect, always to reduce hearing damage, can be a net effect resulting from complex interactions between OC subcomponents (crossed and uncrossed OC pathways). The interactions between these subcomponents vary with type of loud sound, suggesting that sound bandwidth may be important in determining how OC pathways modulate loud sound\u2010induced hearing loss. This dependency was examined and here it is reported that OC pathways do not alter cochlear hearing losses caused by loud noise with a 2\u2010kHz\u2010wide bandwidth intermediate between the loud sounds of previous studies. Increasing stimulus bandwidth even slightly more, to use a loud 3.5\u2010kHz\u2010wide bandwidth noise as the damaging sound, once again revealed OC modulation of cochlear hearing loss. The fact that OC pathways do not modulate cochlear hearing losses induced by loud 2\u2010kHz\u2010wide noise was demonstrated in three very different test conditions in which OC pathways modulate hearing losses caused by narrower or broader bandwidth sounds. This confirmed that the absence of centrifugal modulation of hearing loss to this particular sound was a robust phenomenon not related to test condition. The absence of overall centrifugal effects was also true at the level of subcomponent pathways; neither crossed nor uncrossed OC pathways individually modulated cochlear hearing losses to the loud 2\u2010kHz\u2010wide noise. This surprising frequency dependency has general implications for centrifugal modulation of cochlear responses.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05246.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T17:28:50Z","timestamp":1165426130000},"page":"3589-3600","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bandwidth determines modulatory effects of centrifugal pathways on cochlear hearing desensitization caused by loud sound"],"prefix":"10.1111","volume":"24","author":[{"given":"R.","family":"Rajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1982.tb07077.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620020044"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90048-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1777873"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.420082"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(82)90054-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114991"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(92)90083-Y"},{"key":"e_1_2_7_10_1","first-page":"36","article-title":"Physiological mechanism underlying the progressive resistance to noise induced hearing loss","volume":"54","author":"Fiorino F.G.","year":"1989","journal-title":"Il Valsalva"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00396-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00192.2002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90166-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90023-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2017899"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.09.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00453630"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(91)90006-U"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.6.2519"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90228-S"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.6.3095"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Pathways for protection from noise\u2010induced hearing loss","volume":"5","author":"LePrell C.G.","year":"2003","journal-title":"Noise Health"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.414956"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1523\/JNEUROSCI.22-10-04241.2002","article-title":"Variation in inter\u2010animal susceptibility to noise damage is associated with \u03b19 acteylcholine receptor subunit expression level","volume":"22","author":"Luebke A.E.","year":"2002","journal-title":"J. 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