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To gain new information from such a classic model, we studied the time\u2010course of the nigrostriatal damage, metabolic changes in the basal ganglia nuclei (cytochrome oxidase activity) and behavioural modifications (rotational response to apomorphine) following unilateral injection of 6\u2010OHDA into the corpus striatum of rat, over a 4\u2010week period. Striatal infusion of 6\u2010OHDA caused early damage of dopaminergic terminals, followed by a slowly evolving loss of dopaminergic cell bodies in the substantia nigra pars compacta, which became apparent during the second week post\u2010injection and peaked at the 28th day post\u2010infusion; the rotational response to apomorphine was already present at the first time point considered (Day 1), and remained substantially stable throughout the 4\u2010week period of observation. The evolution of the nigrostriatal lesion was accompanied by complex changes in the metabolic activity of the other basal ganglia nuclei investigated (substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and subthalamic nucleus), which led, ultimately, to a generalized, metabolic hyperactivity, ipsilaterally to the lesion. However, peculiar patterns of metabolic activation, or inhibition, characterized the post\u2010lesional responses of each nucleus, in the early and intermediate phases, with peculiar response profiles that varied closely related to the functional position occupied within the basal ganglia circuitry.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05285.x","type":"journal-article","created":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T11:58:52Z","timestamp":1169639932000},"page":"397-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Time\u2010course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6\u2010hydroxydopamine in the rat: new clues from an old model"],"prefix":"10.1111","volume":"25","author":[{"given":"Fabio","family":"Blandini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Levandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Bazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Nappi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Therese","family":"Armentero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90240-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.09.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1096\/fj.03-0576fje","article-title":"High\u2010frequency stimulation of both zona incerta and subthalamic nucleus induces a similar normalization of basal ganglia metabolic activity in experimental parkinsonism","volume":"18","author":"Benazzouz A.","year":"2004","journal-title":"FASEB J."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(91)90242-C"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903070205"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/81834"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-01-00308.1997"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.03.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01495.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.104"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00067-2"},{"key":"e_1_2_7_14_1","first-page":"413","article-title":"Effect of 6\u2010hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons","volume":"174","author":"Breese G.R.","year":"1970","journal-title":"J. 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