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Here we showed that short\u2010term synaptic plasticity was impaired in the hippocampal area CA1 of JNK1\u2010deficient (JNK1<jats:sup>\u2013\/\u2013<\/jats:sup>) mice; these mice showed normal LTP in response to a strong tetanus and no alteration of <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate receptor\u2010dependent long\u2010term depression (LTD) in the hippocampus. However, LTD induced either by group I metabotropic glutamate receptors (mGluRs) agonist dihydroxyphenylglycine or by paired\u2010pulse low\u2010frequency stimulation was absent in both the JNK1<jats:sup>\u2013\/\u2013<\/jats:sup> slices and in JNK inhibitor anthrax [1, 9\u2010<jats:italic>cd<\/jats:italic>] pyrazol\u20106(2<jats:italic>H<\/jats:italic>)\u20101 (SP600125)\u2010pretreated slices. Induction of mGluR\u2010dependent LTD resulted in an increase in phosphorylation of JNK1 substrates, including p\u2010c\u2010Jun and p\u2010ATF2 in wild\u2010type (WT) mice, and these increases failed to occur in the JNK1<jats:sup>\u2013\/\u2013<\/jats:sup> or SP600125\u2010pretreated mice. These results demonstrated that JNK1 played a crucial role in the short\u2010term synaptic plasticity and mGluR\u2010dependent LTD, whereas hippocampus LTP was not affected by JNK1 deficiency.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.05300.x","type":"journal-article","created":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T11:58:52Z","timestamp":1169639932000},"page":"391-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["JNK1 contributes to metabotropic glutamate receptor\u2010dependent long\u2010term depression and short\u2010term synaptic plasticity in the mice area hippocampal CA1"],"prefix":"10.1111","volume":"25","author":[{"given":"Xin\u2010Mei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Shan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanaga","family":"Sabapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di\u2010Yun","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2000.4000"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251194298"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02524.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00739.2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00094-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03037.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04335.2002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2003.11.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00941-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07168.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.23-19-07317.2003","article-title":"p38 MAP kinase mediates both short\u2010term and long\u2010term synaptic depression in aplysia","volume":"23","author":"Guan Z.","year":"2003","journal-title":"J. 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