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Using \u00b5\u2010opioid receptor (MOP)\u2010knockout mice we addressed whether endogenous opioids influence ischemia\u2010induced enhancement of hippocampal neurogenesis. Permanent middle cerebral artery occlusion (MCAO) produced similar corticostriatal infarcts in MOP\u2010knockout and wildtype mice. Analyses of BrdU\/doublecortin\u2010colabelled cells in the granule cell layer 14\u2003days after MCAO showed that ischemic knockouts contained more immature neurons generated during days\u20039\u201311 than wildtypes. After 29\u2003days, similar quantities of BrdU\/NeuN\u2010labelled cells were found in ischemic knockout and wildtype mice, suggesting that granule cells that were formed in excess during days\u20039\u201311 in the knockouts were eliminated by day\u200329. Neurogenesis was similar in knockout and wildtype mice subjected to sham operation. In addition to a transient increase in neurogenesis, MCAO caused a transient up\u2010regulation of preprodynorphin and preproenkephalin mRNA expression in the granule cell layer. Our findings suggest that activated signalling via endogenous opioids and the MOP limits the enhanced generation of neuronal cells after ischemic corticostriatal lesions.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2008.06111.x","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T15:35:21Z","timestamp":1204904121000},"page":"1311-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Endogenous opioids inhibit ischemia\u2010induced generation of immature hippocampal neurons via the \u00b5\u2010opioid receptor"],"prefix":"10.1111","volume":"27","author":[{"given":"Angela","family":"Kolodziej","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Stumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"H\u00f6llt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1707"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01611.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03328.1995"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1523\/JNEUROSCI.16-24-08123.1996","article-title":"Endogenous activation of mu and delta\u20101 opioid receptors is required for long\u2010term potentiation induction in the lateral perforant path: dependence on GABAergic inhibition","volume":"16","author":"Bramham C.R","year":"1996","journal-title":"J. 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