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However, unlike mammalian niches where several generations of neuronal precursors co\u2010exist, the lineage of precursor cells in crayfish is spatially separated allowing the influence of environmental and endogenous regulators on specific generations in the neuronal precursor lineage to be defined. Experiments also demonstrate that the first\u2010generation neuronal precursors in the crayfish <jats:italic>Procambarus clarkii<\/jats:italic> are not self\u2010renewing. A source external to the neurogenic niche must therefore provide cells that replenish the first\u2010generation precursor pool, because although these cells divide and produce a continuous efflux of second\u2010generation cells from the niche, the population of first\u2010generation niche precursors is not diminished with growth and aging. <jats:italic>In vitro<\/jats:italic> studies show that cells extracted from the hemolymph, but not other tissues, are attracted to and incorporated into the neurogenic niche, a phenomenon that appears to involve serotonergic mechanisms. We propose that, in crayfish, the hematopoietic system may be a source of cells that replenish the niche cell pool. These and other studies reviewed here establish decapod crustaceans as model systems in which the processes underlying adult neurogenesis, such as stem cell origins and transformation, can be readily explored. Studies in diverse species where adult neurogenesis occurs will result in a broader understanding of fundamental mechanisms and how evolutionary processes may have shaped the vertebrate\/mammalian condition.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2011.07802.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T21:40:25Z","timestamp":1316468425000},"page":"870-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Adult neurogenesis in the decapod crustacean brain: a hematopoietic connection?"],"prefix":"10.1111","volume":"34","author":[{"given":"Barbara S.","family":"Beltz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne L.","family":"Benton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Sandeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20864"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11217"},{"key":"e_1_2_8_4_1","first-page":"245","article-title":"\u00c9tude compar\u00e9e de l\u2019organe deutoc\u00e9r\u00e9bral des Macroures Reptantia et des Anomoures (Crustac\u00e9s D\u00e9capodes)","volume":"111","author":"Bazin F.","year":"1970","journal-title":"Arch. 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