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In rats with neonatal hemidecortication, corticospinal fibers originating from the undamaged side of the sensorimotor cortex issue collateral sprouts to the ipsilateral spinal gray matter that mediate cortical excitation to ipsilateral forelimb motoneurons and compensate for the deficit in forelimb movements. The present study was designed to investigate the origins of the ipsilateral corticospinal projection in neonatally hemidecorticated rats. Corticospinal neurons (CSNs) were labeled in adults by injecting retrograde neural tracers, cholera toxin subunit B with different fluorescent probes, into either side of the cervical spinal gray matter. In the undamaged cortex, double\u2010labeled neurons were rarely found. CSNs with contralateral projections (contra\u2010CSNs) and those with ipsilateral projections (ipsi\u2010CSNs) were distributed both in the rostral forelimb motor area (RFA) and the caudal forelimb motor area (CFA). However, there was a difference in the distributions of the ipsi\u2010CSNs between the two forelimb areas. Whereas the distribution of the ipsi\u2010CSNs largely overlapped with that of the contra\u2010CSNs in the RFA, the ipsi\u2010CSNs tended to be segregated from the contra\u2010CSNs in the CFA. The results suggested that the RFA and the CFA contribute to the compensatory process in different ways.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2011.07866.x","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T08:55:11Z","timestamp":1320051311000},"page":"1453-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Differential contributions of rostral and caudal frontal forelimb areas to compensatory process after neonatal hemidecortication in rats"],"prefix":"10.1111","volume":"34","author":[{"given":"Tatsuya","family":"Umeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Isa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90427-B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02259101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1523\/JNEUROSCI.17-01-00251.1997","article-title":"Postnatal development of corticospinal projections from motor cortex to the cervical enlargement in the macaque monkey","volume":"17","author":"Armand J.","year":"1997","journal-title":"J. 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