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We show that loss of SRF in DA neurons does not affect their viability and does not influence dopamine\u2010dependent behaviors. However, ablation of SRF causes exacerbated sensitivity to 1\u2010methyl 4\u2010phenyl 1,2,3,6\u2010tetrahydropyridine (MPTP), leading to significantly greater loss of DA neurons in the substantia nigra, compared with DA neurons located in the ventral tegmental area. In addition, loss of SRF decreases levels of the anti\u2010apoptotic proteins brain\u2010derived neurotrophic factor (BDNF) and Bcl\u20102, a plausible underlying cause of increased sensitivity to oxidative stress. These observations support the notion that dysfunction of the SRF\u2010activating mitogen\u2010associated kinase pathway may be part of Parkinson\u2019s disease etiology.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08003.x","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T03:24:13Z","timestamp":1329967453000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP\u2010induced oxidative 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