{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:12:12Z","timestamp":1787807532809,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The orexin\/hypocretin system is involved in several addiction\u2010related behaviors. In the present experiments, we examined the involvement of orexin in heroin reinforcement and relapse by administering the orexin 1 receptor antagonist SB\u2010334867 prior to heroin self\u2010administration or prior to cue\u2010induced or heroin\u2010induced reinstatement of extinguished heroin seeking in male Sprague Dawley rats. SB\u2010334867 (30\u2003mg\/kg, intraperitoneal) reduced heroin intake during self\u2010administration under fixed ratio\u20101 and progressive ratio schedules. SB\u2010334867 also attenuated reinstatement of heroin seeking elicited by cues, but not reinstatement elicited by a heroin prime. These results indicate that orexin antagonism reduces heroin self\u2010administration, and they support a role for orexin in cue\u2010triggered drug relapse.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08013.x","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T01:35:00Z","timestamp":1329960900000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Orexin\u200a\/\u200ahypocretin 1 receptor antagonist reduces heroin self\u2010administration and cue\u2010induced heroin seeking"],"prefix":"10.1111","volume":"35","author":[{"given":"Rachel J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Aston\u2010Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.060"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.024"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6096-08.2009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.10.068"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3207-04.2004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507480102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.03.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.02.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07065.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03106.2003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90192-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.08.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04071"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.05.025"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808023105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.07.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000423"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.03.045"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01088.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.08.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5129-07.2008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706789"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1792-0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.9.2.131"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.6.1.22"},{"key":"e_1_2_7_30_1","article-title":"VTA afferents controlling cued reinstatement of cocaine seeking","author":"Mahler S.V.","year":"2010","journal-title":"Neuroscience Meeting Planner Online"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.027"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2009.07.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2761-05.2006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1366-x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3565(25)27954-X","article-title":"Cocaine\u2010reinforced behavior in rats: effects of reinforcement magnitude and fixed\u2010ratio size","volume":"161","author":"Pickens R.","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00343-2"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1136-5"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00153-0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.10.012"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2092"},{"key":"e_1_2_7_42_1","volume-title":"J. Neurosci.","author":"Sartor G.C.","year":"2012"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709000054"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246022"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.006"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.035"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.035"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.028"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.55.090902.141545"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703953"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06844.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.06.042"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01717-5"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2082-6"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246140"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1190-3"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.5.485"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06960"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2012.08013.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2012.08013.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T14:32:32Z","timestamp":1742567552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2012.08013.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,22]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1460-9568.2012.08013.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08013.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,22]]},"assertion":[{"value":"2012-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}