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Visual recognition memory relies on synaptic plasticity in the perirhinal cortex, but little is known about the mechanisms involved in emotional enhancement of this form of memory. The results of the present study, performed in rat brain slices, show for the first time that the amygdala input to the perirhinal cortex undergoes synaptic plasticity. Stimulation in the amygdala resulted in long\u2010term potentiation (LTP) in perirhinal cortex that was dependent on \u03b2\u2010adrenoceptors and L\u2010type voltage\u2010dependent calcium channels (L\u2010VDCCs) but was NMDAR\u2010independent. In contrast, intracortical perirhinal stimulation resulted in LTP that was NMDAR\u2010dependent but \u03b2\u2010adrenoceptor\u2010 and L\u2010VDCC\u2010independent. In addition, the present results provide the first evidence that stimulation of the amygdala can reduce the threshold for LTP in the perirhinal cortex. Interestingly, this associative form of LTP requires \u03b2\u2010adrenoceptor activation but not NMDA or L\u2010VDCC activation. Knowing the mechanisms that control amygdala\u2013perirhinal cortex interactions will allow better understanding of how emotionally charged visual events are remembered, and may help to understand how memories can consolidate and become intrusive in anxiety\u2010related disorders.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08146.x","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T06:09:18Z","timestamp":1337753358000},"page":"2421-2427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Synaptic plasticity from amygdala to perirhinal cortex: a possible mechanism for emotional enhancement of visual recognition 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