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However, it remains unknown whether CRH\u2013CRHR1 signaling is involved in early\u2010life stress\u2010induced anxiety\u2010related behavior in adult animals. In the present study, we used conditional forebrain CRHR1 knockout (CRHR1\u2010CKO) mice and examined the potential role of forebrain CRHR1 in the anxiogenic effects of early\u2010life stress. As adults, wild\u2010type mice that received unstable maternal care during the first postnatal week showed reduced body weight gain and increased anxiety levels in the open field test, which were prevented in stressed CRHR1\u2010CKO mice. In the light\u2013dark box test, control CRHR1\u2010CKO mice were less anxious, but early\u2010life stress increased anxiety levels in both wild\u2010type and CRHR1\u2010CKO mice. In the elevated plus maze test, early\u2010life stress had only subtle effects on anxiety\u2010related behavior. Moreover, early\u2010life stress did not alter the basal home cage activity and gene expression levels of key hypothalamic\u2010pituitary\u2010adrenal axis regulators in adult wild\u2010type and CRHR1\u2010CKO mice, but enhanced neuroendocrine reactivity to acute immobilization stress in CRHR1\u2010CKO mice. Our findings highlight the importance of forebrain CRHR1 in modulating some of the anxiogenic effects of early\u2010life stress, and suggest that other neural circuits are also involved in the programming effects of early\u2010life stress on anxiety\u2010related behavior.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08148.x","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T10:27:45Z","timestamp":1338892065000},"page":"2360-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Early\u2010life stress\u2010induced anxiety\u2010related behavior in adult mice partially requires forebrain corticotropin\u2010releasing hormone receptor 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