{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:58:54Z","timestamp":1791104334726,"version":"4.1.0"},"reference-count":221,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson\u2019s disease (PD) has for decades been considered a pure motor disorder and its cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta and to nigral Lewy body pathology. However, there has more recently been a shift in the conceptualization of the disease, and its pathological features have now been recognized as involving several other areas of the brain and indeed even outside the central nervous system. There are a corresponding variety of intrinsic non\u2010motor symptoms such as autonomic dysfunction, cognitive impairment, sleep disturbances and neuropsychiatric problems, which cannot be explained exclusively by nigral pathology. In this review, we will focus on cognitive impairment and affective symptoms in PD, and we will consider whether, and how, these deficits can best be modelled in rodent models of the disorder. As only a few of the non\u2010motor symptoms respond to standard DA replacement therapies, the quest for a broader therapeutic approach remains a major research effort, and success in this area in particular will be strongly dependent on appropriate rodent models. In addition, better understanding of the different models, as well as the advantages and disadvantages of the available behavioural tasks, will result in better tools for evaluating new treatment strategies for PD patients suffering from these neuropsychological symptoms.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08162.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T06:31:50Z","timestamp":1340087510000},"page":"1894-1907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Cognitive dysfunction and depression in Parkinson\u2019s disease: what can be learned from rodent models?"],"prefix":"10.1111","volume":"35","author":[{"given":"Hanna S.","family":"Lindgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.189"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn238"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90576-W"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.05.017"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0222-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.01.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04017.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03325.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00065-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0538-8"},{"key":"e_1_2_10_13_1","first-page":"108","article-title":"Attentional deficits in Parkinson\u2019s disease: partial reversibility with naphtoxazine (SDZ NVI\u2010085), a selective noradrenergic alpha 1 agonist","volume":"21","author":"Bedard M.A.","year":"1998","journal-title":"Clin. Neuropharmacol."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.03.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.06.008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq079"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200069"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-1301-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21642"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10524"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.114.2.431"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.093146"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21541"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.14.4546"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21677"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(10)84002-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.01.016"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(83)90138-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/313679a0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90059-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.04.017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.01.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0319-07.2007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005482"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(03)00108-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.024"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301153"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.01.039"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2550-11.2011"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01338.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.4.443"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02803.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0862-4"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.129"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9091-4"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb12983.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318236ef60"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21966"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0024348"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)91084-3"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90860-P"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111097"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90121-3"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(08)70006-3"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03637.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.10.010"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350428"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007725"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(82)90024-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00076-5"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.07.033"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00616.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198879000300102"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32833e7e80"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq221"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.04.005"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.023"},{"key":"e_1_2_10_73_1","article-title":"Impaired reversal learning in transgenic mice overexpressing human wildtype alpha\u2010synuclein","author":"Fleming S.M.","year":"2008","journal-title":"Soc. Neurosci."},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh067"},{"key":"e_1_2_10_75_1","first-page":"35","article-title":"The Lewy body in Parkinson\u2019s disease","volume":"45","author":"Forno L.S.","year":"1987","journal-title":"Adv. Neurol."},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.06.013"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.08.014"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2001.00402.x"},{"key":"e_1_2_10_79_1","first-page":"7","article-title":"Depression antedating the onset of Parkinson\u2019s disease","volume":"45","author":"Fukunishi I.","year":"1991","journal-title":"Jpn. J. Psychiatry Neurol."},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.12.017"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.002"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.009"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8059-y"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988709358591"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.06.030"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.115"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.16.2.178"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270405"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-45295-0_16"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-02-00582.1989"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20324"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390801982734"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.01.028"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.12.035"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00701.x"},{"key":"e_1_2_10_96_1","first-page":"3","article-title":"Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys","volume":"13","author":"Jacobsen C.F.","year":"1936","journal-title":"J. Comp. Psychol."},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0056632"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.08.022"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068483"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.04.012"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01789-6"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.07.023"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0597-x"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.01.023"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70212-X"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23305"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804073181402"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/33416"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.018"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5280.1399"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-106"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<613::AID-MDS1005>3.0.CO;2-F"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.09.006"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22611"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245167"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823561"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1066"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/106.2.257"},{"key":"e_1_2_10_119_1","first-page":"987084","article-title":"Effects of human alpha\u2010synuclein A53T\u2010A30P mutations on SVZ and local olfactory bulb cell proliferation in a transgenic rat model of Parkinson disease","volume":"2011","author":"Lelan F.","year":"2011","journal-title":"Parkinsons Dis."},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0405"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.4.557"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.02.008"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10280"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.02.014"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.09.033"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(10)84004-X"},{"key":"e_1_2_10_127_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JPD-2011-11043","article-title":"Mouse models of cognitive deficits due to alpha\u2010synuclein pathology","volume":"1","author":"Magen I.","year":"2011","journal-title":"J. Parkinsons Dis."},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.2.178"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1983.tb00320.x"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.6.672"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22307"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019338"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.04.012"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073446"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000446"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.7008"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.11.008"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07608.x"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_10_140_1","first-page":"365","article-title":"Allocentric spatial learning by hippocampectomized rats: a further test of the \u201cspatial mapping\u201d and \u201cworking memory\u201d theories of hippocampal function","volume":"38","author":"Morris R.G.","year":"1986","journal-title":"Q. J. Exp. Psychol. B"},{"key":"e_1_2_10_141_1","article-title":"Mice overexpressing human wildtype alpha\u2010synuclein under the Thy\u20101 promoter exhibit anomalies in behavioral tests of anxiety","author":"Mulligan C.K.","year":"2008","journal-title":"Soc. Neurosci."},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10472"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180516.69442.95"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.009"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2647"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01405-1"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3040-07.2008"},{"key":"e_1_2_10_148_1","first-page":"647","article-title":"Dissociative effects of selective lesions in the caudate nucleus of cats and rats","volume":"35","author":"Oberg R.G.","year":"1975","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.03.003"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0898-963"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.003"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1993.tb00480.x"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0291-0"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91444-6"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892905775008661"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00559.x"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_10_158_1","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt R.D.","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-6"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03885.x"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9087-0"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7427(03)00077-7"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0013487"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21803"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh445"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.19.2.87"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1154-7"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10231"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.695"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16305-8"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2560-5"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.004"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540310050016"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn054"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90993-9"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06657.x"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0483-3"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00525.2009"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0124"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<669::AID-MDS1011>3.0.CO;2-5"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90223-0"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0630-x"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.11.010"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.67"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13515"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428203"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.12.020"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.035"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(85)90640-5"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2008.09.008"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550020087019"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(97)00452-8"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002839"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1495-09.2009"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235545"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8021"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.06.006"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.05.006"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.03.012"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.109207"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(68)90164-7"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.1971.tb11001.x"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.3181\/0707-MR-193"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200097"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.07.015"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2011.00698.x"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017401"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9574-5"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ebdd79"},{"key":"e_1_2_10_210_1","first-page":"24","article-title":"Sleep disturbance in Parkinson\u2019s disease: a human response to illness","volume":"31","author":"Wells T.","year":"2009","journal-title":"Can J. Neurosci. Nurs."},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(85)90165-2"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(87)90250-6"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2000.93"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm111"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70114-5"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2356-7"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.753"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20305"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.116"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05812.x"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4055.1211"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90112-N"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1460-9568.2012.08162.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1460-9568.2012.08162.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T19:20:56Z","timestamp":1694460056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2012.08162.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":221,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1460-9568.2012.08162.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08162.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"2012-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}