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Whether OPN5 is functionally involved in light detection is unknown. Daylength plays a critical role in regulating the neuroendocrine control of reproduction in birds. The presence of light during a \u2018photoinducible\u2019 phase of the circadian cycle, which occurs 12\u201316\u2003h after dawn, results in marked changes in hypothalamic gene expression. These changes ultimately control gonadotropin release from the pituitary gland that, in turn, stimulates gonadal development. In this study, we first measured OPN5 expression in the mediobasal hypothalamus (MBH) in border canaries during the photoinducible period in relation to thyrotropin (TSH) \u03b2\u2010subunit mRNA expression, which is implicated in the control of avian reproduction. Second, the knockdown of OPN5 via small interfering RNA antisense in the MBH revealed that there is an inhibitory input in the photoinduced regulation of <jats:italic>TSH\u03b2<\/jats:italic> mRNA expression. Our data indicate that a decrease in <jats:italic>OPN5<\/jats:italic> mRNA expression is associated with the facilitation in <jats:italic>TSH\u03b2<\/jats:italic> mRNA expression in the MBH, a critical step for the light\u2010induced increase in gonadal recrudescence. We hypothesise that the removal of an inhibitory input by OPN5 in birds may be a step that occurs during the photoinducible period. Given the distribution of OPN5 in the brain and periphery, this suggests a possible multifunctional role for light information in regulating other physiological processes.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08209.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T05:07:27Z","timestamp":1341810447000},"page":"2859-2865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Disruption of neuropsin mRNA expression via RNA interference facilitates the photoinduced increase in thyrotropin\u2010stimulating subunit \u03b2 in birds"],"prefix":"10.1111","volume":"36","author":[{"given":"Tyler J.","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory F.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"669","article-title":"Le role des yeux dans l\u2019action stimulante de la lumiere sure le development testiculaire chez le canard [The role of the eyes for light stimulation on the development of testicles in the duck]","volume":"118","author":"Benoit J.","year":"1935","journal-title":"CR Soc. 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