{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:29:52Z","timestamp":1794040192291,"version":"4.8.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early odor preference learning in rats provides a simple model for studying learning and memory. Learning results in an enhanced output from mitral cells, which carry odor information from the olfactory bulb to the olfactory cortex. Mitral cell NMDA receptors (NMDARs) are critically involved in plasticity at the olfactory nerve to mitral cell synapse during odor learning. Here we provide evidence that L\u2010type calcium channels (LTCCs) provide an additional and necessary source of calcium for learning induction. LTCCs are thought to act downstream of NMDARs to bridge synaptic activation and the transcription of the plasticity\u2010related proteins necessary for 24\u2010h learning and memory. Using immunohistochemistry, we have demonstrated that LTCCs are present in the mitral cell and are primarily located on mitral cell proximal dendrites in neonate rats. Behavioral experiments demonstrate that inhibiting the function of LTCCs via intrabulbar infusion of nimidopine successfully blocks learning induced by pairing isoproterenol infusion with odor, while activation of LTCCs via an intrabulbar infusion of BayK\u20108644 rescues isoproterenol\u2010induced learning from a D\u2010APV block. Interestingly, the infusion of BayK\u20108644 paired with odor is by itself not sufficient to induce learning. Synaptoneurosome Western blot and immunohistochemistry measurement of synapsin\u2003I phosphorylation following BayK\u20108644 infusion suggest LTCCs are involved in synaptic release. Finally, odor preference can be induced by gabazine disinhibition of mitral cells, and NMDAR opening is sufficient for the gabazine\u2010induced learning. These results provide the first evidence that NMDARs and LTCCs interact to permit calcium\u2010dependent mitral cell plasticity during early odor preference learning.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2012.08210.x","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T14:19:22Z","timestamp":1341497962000},"page":"3134-3141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interaction of NMDA receptors and L\u2010type calcium channels during early odor preference learning in 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